{"id":"W4389621524","doi":"10.1681/asn.0000000000000271","title":"Effects of Empagliflozin on Fluid Overload, Weight, and Blood Pressure in CKD","year":2023,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Body Composition Measurement Techniques","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Health Data Research UK; National Heart, Lung, and Blood Institute; National Center for Advancing Translational Sciences; Medical Research Council; Centers for Disease Control and Prevention; Fresenius Medical Care North America; Astellas Pharma; National Institute on Minority Health and Health Disparities; Deutsche Forschungsgemeinschaft; Amicus Therapeutics; University of Oxford; Regeneron Pharmaceuticals; National Institutes of Health; Biomedical Research Council; Kidney Research UK; Novo Nordisk; National Institute for Health and Care Research; Pfizer; Moderna; British Heart Foundation; Alnylam Pharmaceuticals; Amgen; European Society of Cardiology; Science Foundation Ireland; Eli Lilly and Company; AstraZeneca; American Heart Association; American Society of Nephrology; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi","keywords":"Empagliflozin; Medicine; Internal medicine; Copeptin; Population; Placebo; Cardiology; Diabetes mellitus; Kidney disease; Type 2 diabetes; Urology; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005106981,0.0001042979,0.0005696795,0.0001110329,0.00002454736,0.000002151632,0.0001643688,0.0000646528,0.000006416735],"category_scores_gemma":[0.00007317444,0.00007149189,0.0002683491,0.000416755,0.0004616171,0.0000343697,0.00006700477,0.0003309495,5.90209e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001869708,"about_ca_system_score_gemma":0.00006613146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002858065,"about_ca_topic_score_gemma":0.000001273022,"domain_scores_codex":[0.9988129,0.0001942993,0.0003912504,0.0001023399,0.0003445497,0.0001546386],"domain_scores_gemma":[0.9986687,0.0002954152,0.0006744878,0.0001844155,0.0001251512,0.0000518855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000496663,0.0002461994,0.01746386,0.0001764471,0.0005214252,0.00001476618,0.0004394037,0.00001075359,0.9397917,0.00002500407,0.04014038,0.0006734271],"study_design_scores_gemma":[0.002666097,0.004752133,0.8083661,0.0003957892,0.0008337941,0.0001651465,0.0001552049,0.0001754963,0.1778068,0.0003362788,0.004262758,0.00008439633],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932604,0.0004735439,0.00002883987,0.005912909,0.00005053049,0.000205742,0.000002533693,0.00001692166,0.0000486103],"genre_scores_gemma":[0.9933705,0.0009692436,0.001963453,0.00352542,0.0001139267,0.000003100258,3.657711e-7,0.00001285696,0.00004115553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7909023,"threshold_uncertainty_score":0.2915355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100247572209583,"score_gpt":0.2692438074211832,"score_spread":0.2582413316990874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}