{"id":"W4389624397","doi":"10.3390/cells12242821","title":"Flavonoids Regulate Redox-Responsive Transcription Factors in Glioblastoma and Microglia","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Fisetin; Transcription factor; Chemistry; Microglia; Cell biology; KEAP1; Carcinogenesis; Reactive oxygen species; Cancer research; Biology; Biochemistry; Quercetin; Antioxidant; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005660304,0.0001345743,0.00009980975,0.0001526045,0.0001191091,0.0001416662,0.00006395996,0.0001447558,0.0006060148],"category_scores_gemma":[0.00005426204,0.00005197457,0.0001417294,0.00007667935,0.0001209093,0.000117496,0.00009906522,0.0001590001,0.0001311501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002567392,"about_ca_system_score_gemma":0.000131764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008445225,"about_ca_topic_score_gemma":0.001294345,"domain_scores_codex":[0.9999584,0.000007016478,0.000002072238,0.000009753285,0.00000831918,0.00001448398],"domain_scores_gemma":[0.9999813,0.000002160037,0.00000681787,0.000001195575,0.000003546624,0.000004951924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000161249,0.00001823369,0.0005260752,0.00003240337,0.00000514327,0.00002427787,0.00002251402,0.00009422272,0.9975841,0.0001066567,0.00003132987,0.001393866],"study_design_scores_gemma":[0.00003314577,0.0003120052,0.0347656,0.00001369808,0.00002826898,0.0001500539,0.0001879167,0.002344608,0.9589888,0.0004997877,0.002666264,0.000009831353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965473,0.001654862,0.001045639,0.00007685151,0.000006432973,0.000008434786,0.0001242156,0.0000182547,0.0005180264],"genre_scores_gemma":[0.9977696,0.0006300214,0.0007442114,0.00003121531,0.00000235169,0.00001283604,0.0001149401,0.000004084001,0.0006906741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008445225,"threshold_uncertainty_score":0.002027273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008101261341654498,"score_gpt":0.2272662905734508,"score_spread":0.2191650292317963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}