{"id":"W4389624397","doi":"10.3390/cells12242821","title":"Flavonoids Regulate Redox-Responsive Transcription Factors in Glioblastoma and Microglia","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Fisetin; Transcription factor; Chemistry; Microglia; Cell biology; KEAP1; Carcinogenesis; Reactive oxygen species; Cancer research; Biology; Biochemistry; Quercetin; Antioxidant; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009453779,0.0001390533,0.0001351051,0.00008093017,0.00003738613,0.00001742323,0.0001004838,0.0001412123,0.00001048912],"category_scores_gemma":[0.00002434571,0.0001413274,0.00005459407,0.000116084,0.00009527637,0.00000362238,0.00005513109,0.00007643775,0.00002243738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001261277,"about_ca_system_score_gemma":0.000020889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001252149,"about_ca_topic_score_gemma":0.00004408801,"domain_scores_codex":[0.9991737,0.000047328,0.0001581479,0.0003328792,0.00005429511,0.0002336358],"domain_scores_gemma":[0.9996562,0.00001391218,0.00003924054,0.0001916455,0.00003087904,0.00006809835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001256463,0.00001538855,0.0009747889,0.00001712844,0.00001317006,0.000004688058,0.0003606618,0.00002402463,0.9967228,0.000006467618,0.001425954,0.0003092996],"study_design_scores_gemma":[0.000418952,0.0001167709,0.0106919,0.00001262572,0.000006457084,0.000001371238,0.0003087065,0.0000217386,0.9819251,0.0001687932,0.006169742,0.0001577962],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991129,0.000275173,0.00003440686,0.00007304358,0.0001621437,0.0001504388,0.00004807106,0.00001687983,0.0001269284],"genre_scores_gemma":[0.9976876,0.0002976725,0.00007654013,0.00005851751,0.00007835779,0.000008578666,0.00007453682,0.0000195451,0.001698634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01479763,"threshold_uncertainty_score":0.5763165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008101261341654498,"score_gpt":0.2272662905734508,"score_spread":0.2191650292317963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}