{"id":"W4389626456","doi":"10.1016/j.immuni.2023.11.005","title":"Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure","year":2023,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":129,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Perelman School of Medicine, University of Pennsylvania; Tara Miller Melanoma Foundation; Damon Runyon Cancer Research Foundation; American Association of Immunologists; National Institutes of Health; Pew Charitable Trusts; Parker Institute for Cancer Immunotherapy; University of Pennsylvania; National Health and Medical Research Council; Doris Duke Charitable Foundation; Ludwig Family Foundation; Mark Foundation For Cancer Research; National Cancer Institute; Institute for Translational Medicine and Therapeutics; W. W. Smith Charitable Trust; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute","keywords":"STAT5; Biology; Effector; Epigenetics; Cell biology; CD8; Cytotoxic T cell; Transcription factor; stat; Immunology; Cancer research; Antigen; Signal transduction; STAT3; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885463,0.0003265818,0.0002332326,0.0001730118,0.0001945508,0.0006197182,0.0002551966,0.0003065258,0.003089522],"category_scores_gemma":[0.0001700291,0.0001348226,0.0002188405,0.00008256926,0.0003978837,0.0003961261,0.0004171068,0.0008838944,0.0006417313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000425256,"about_ca_system_score_gemma":0.0003473003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003308938,"about_ca_topic_score_gemma":0.001094163,"domain_scores_codex":[0.9996959,0.00003085831,0.0000135219,0.00005099075,0.00005699241,0.0001518165],"domain_scores_gemma":[0.9998553,0.00001659928,0.00003529343,0.00001711585,0.00001322893,0.00006243718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004721286,0.00003773997,0.002054868,0.0000532556,0.000007849458,0.0001153147,0.00003848524,0.0002065265,0.9926939,0.0006257555,0.000223081,0.003471021],"study_design_scores_gemma":[0.00009370654,0.001490476,0.05898977,0.00004893573,0.0000554006,0.000672843,0.0005967346,0.004637273,0.9245142,0.001364136,0.007515378,0.0000211794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995612,0.0008238479,0.001165088,0.0001772201,0.00006620135,0.000008860388,0.000160889,0.00009730022,0.001888501],"genre_scores_gemma":[0.9974694,0.0001353752,0.0003389074,0.0001006519,0.00001461178,0.000004457103,0.0001998409,0.00001912886,0.001717674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003089522,"threshold_uncertainty_score":0.01033545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02029630189196774,"score_gpt":0.2375551104599757,"score_spread":0.2172588085680079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}