{"id":"W4389627890","doi":"10.1093/jalm/jfad092","title":"Developing <i>DPYD</i> Genotyping Method for Personalized Fluoropyrimidines Therapy","year":2023,"lang":"en","type":"article","venue":"The Journal of Applied Laboratory Medicine","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"DPYD; Dihydropyrimidine dehydrogenase; Genotyping; Sanger sequencing; Genotype; Pharmacogenetics; Medicine; Molecular biology; Population; Pharmacology; Internal medicine; Biology; Genetics; Chemotherapy; Thymidylate synthase; Mutation; Gene; Fluorouracil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001527499,0.0007416038,0.0008879991,0.001189366,0.000298976,0.0008837259,0.0007010702,0.001222381,0.001764959],"category_scores_gemma":[0.002505224,0.0003969962,0.0006578775,0.0006353889,0.0003680486,0.0004382454,0.0005570796,0.0008028349,0.001326305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004324841,"about_ca_system_score_gemma":0.0005558162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332936,"about_ca_topic_score_gemma":0.001804763,"domain_scores_codex":[0.9977609,0.0005579804,0.0001207964,0.0007642076,0.000648376,0.0001477063],"domain_scores_gemma":[0.9991229,0.0002460179,0.0002213326,0.00008790242,0.0002639343,0.00005789409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006191368,0.0002196577,0.08305684,0.0007707109,0.0002811068,0.0005461295,0.0002671469,0.003906186,0.695986,0.001338243,0.005327837,0.2076811],"study_design_scores_gemma":[0.0001861717,0.001160488,0.08253023,0.0002211094,0.0007837791,0.004529576,0.0002051391,0.08527649,0.7797738,0.002687632,0.04241986,0.0002256281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3554207,0.009509017,0.6121704,0.001636987,0.0005481546,0.0008123573,0.005404628,0.004782469,0.009715327],"genre_scores_gemma":[0.5782924,0.002663221,0.4081776,0.00153731,0.0001857893,0.000596954,0.003482708,0.0002882599,0.004775744],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001764959,"threshold_uncertainty_score":0.008078277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06072018721072103,"score_gpt":0.3637708316552087,"score_spread":0.3030506444444877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}