{"id":"W4389638856","doi":"10.1101/2023.12.12.571247","title":"Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics","keywords":"Proteasome; Biology; Epigenetics; Protein subunit; DNA repair; Gene; DNA methylation; Ubiquitin; Genetics; Gene expression; Cell biology; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002409459,0.0001220975,0.0001586733,0.0006268555,0.00007909926,0.0002486048,0.00008204731,0.0001460129,0.005216279],"category_scores_gemma":[0.0002184042,0.00006053278,0.0001004317,0.0004371554,0.0001120866,0.00007739915,0.0001098084,0.0001429049,0.0006668745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001448546,"about_ca_system_score_gemma":0.00008569096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006829977,"about_ca_topic_score_gemma":0.0007381422,"domain_scores_codex":[0.9999315,0.00001184067,0.000003744612,0.00002227166,0.00002065262,0.00001009285],"domain_scores_gemma":[0.9999398,0.00001828362,0.00001375441,0.000009319106,0.000007859263,0.00001097014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002080295,0.00007587973,0.1808665,0.0001971857,0.0001606913,0.0003187767,0.0001231611,0.001724916,0.7558897,0.0009009266,0.006191617,0.05147048],"study_design_scores_gemma":[0.00005996954,0.0002460872,0.7931631,0.00002863076,0.0001678847,0.001877246,0.0001532254,0.004127033,0.1809839,0.001694184,0.0174813,0.00001732238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743118,0.003986453,0.005770874,0.0004481444,0.00006490129,0.00003697407,0.01061755,0.0003470017,0.004416298],"genre_scores_gemma":[0.9862545,0.000996016,0.00422192,0.00006524639,0.00003510325,0.00002501559,0.003990748,0.00004990111,0.004361494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005216279,"threshold_uncertainty_score":0.01745015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01894922254147497,"score_gpt":0.2470326374587416,"score_spread":0.2280834149172666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}