{"id":"W4389697195","doi":"10.1126/sciadv.adj2417","title":"Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Traumatic Brain Injury and Neurovascular Disturbances","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Memantine; Medicine; Anesthesia; Neuroprotection; Traumatic brain injury; Cortical spreading depression; NMDA receptor; Ketamine; Pharmacology; Migraine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001556441,0.0005368231,0.0005573622,0.0002565719,0.0001297941,0.0001671193,0.0003382481,0.0002586831,0.001034394],"category_scores_gemma":[0.0002272953,0.00008874958,0.0001629324,0.0001185705,0.0002603887,0.000175225,0.0001081064,0.0004940036,0.0001870217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001395736,"about_ca_system_score_gemma":0.00015377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002243013,"about_ca_topic_score_gemma":0.0007336313,"domain_scores_codex":[0.9999183,0.00001755486,0.00001025292,0.00001037298,0.0000170187,0.00002637132],"domain_scores_gemma":[0.9999057,0.0000108022,0.00003798313,0.00001145496,0.0000077209,0.00002628925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02184637,0.004249203,0.001475621,0.0004967056,0.0001854279,0.0002147484,0.00008050599,0.0005133182,0.8931988,0.0001312499,0.0004715554,0.07713663],"study_design_scores_gemma":[0.01043205,0.2744371,0.04384293,0.0001138437,0.000416832,0.001464243,0.0001527838,0.001972938,0.6631988,0.0003021101,0.003622662,0.00004361383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982241,0.001040602,0.0002020976,0.00003690197,0.00002171124,0.00003074695,0.00004724733,0.00003311993,0.0003635694],"genre_scores_gemma":[0.9980082,0.001001101,0.0002638127,0.0000382695,0.00003269122,0.00004931742,0.0001109166,0.000003268468,0.0004924826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034394,"threshold_uncertainty_score":0.003460467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01799963454620318,"score_gpt":0.2948369807961391,"score_spread":0.2768373462499359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}