{"id":"W4389697195","doi":"10.1126/sciadv.adj2417","title":"Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Traumatic Brain Injury and Neurovascular Disturbances","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft","keywords":"Memantine; Medicine; Anesthesia; Neuroprotection; Traumatic brain injury; Cortical spreading depression; NMDA receptor; Ketamine; Pharmacology; Migraine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001187636,0.000173964,0.0002925511,0.0002976866,0.0005276814,0.00009860602,0.0001184503,0.00004653294,0.000008144741],"category_scores_gemma":[0.001623746,0.0001451167,0.0001186758,0.00171815,0.0005040985,0.001195939,0.00007222411,0.0001974959,0.00002159414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002336038,"about_ca_system_score_gemma":0.00008288211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000554305,"about_ca_topic_score_gemma":0.000006000505,"domain_scores_codex":[0.9978974,0.00007249287,0.0003317792,0.0006297888,0.0006675555,0.0004009588],"domain_scores_gemma":[0.9991333,0.0002443501,0.00009969746,0.0002913659,0.00006880423,0.0001625184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001025698,0.00006827032,0.01061623,0.0002981805,0.00004871004,0.00004421761,0.0008570876,0.00001877853,0.8513277,0.001121325,0.00004163157,0.1354553],"study_design_scores_gemma":[0.001664093,0.00126548,0.7407058,0.0007922957,0.0003534327,0.0001500786,0.002561775,0.003032763,0.2447481,0.002308591,0.001883724,0.0005338442],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954346,0.0006834571,0.001435751,0.0007848972,0.0005723878,0.0004103454,0.000002102852,0.0002505227,0.0004258906],"genre_scores_gemma":[0.9985183,0.0001111131,0.000579216,0.000517422,0.00007767606,0.00002695867,0.00001036044,0.00001769321,0.0001412272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7300896,"threshold_uncertainty_score":0.5917687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01799963454620318,"score_gpt":0.2948369807961391,"score_spread":0.2768373462499359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}