{"id":"W4389720846","doi":"10.1101/2023.12.13.571549","title":"Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal; McGill University; Université Laval; Montreal Neurological Institute and Hospital","funders":"Health Canada; Mitacs; Consejo Nacional de Ciencia y Tecnología; Fondation Brain Canada; ALS Society of Canada; BioMarin Pharmaceutical","keywords":"Proteostasis; Heat shock protein; Histone deacetylase; Biology; Neurodegeneration; HSF1; Histone deacetylase inhibitor; Heat shock; Cell biology; Neuroprotection; Chromatin remodeling; Protein aggregation; Hsp70; Histone; Neuroscience; Biochemistry; Medicine; Gene; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002969285,0.0005415832,0.0006799472,0.0003781129,0.0002816012,0.0003783155,0.0004015323,0.0003857503,0.001197971],"category_scores_gemma":[0.0001007462,0.0001974428,0.0004764407,0.0002197582,0.0003038505,0.000220509,0.0002180474,0.001132531,0.0005063564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006553793,"about_ca_system_score_gemma":0.0004214023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00270686,"about_ca_topic_score_gemma":0.007415273,"domain_scores_codex":[0.9996898,0.00004359647,0.00003891787,0.00007484059,0.00007427631,0.00007857062],"domain_scores_gemma":[0.9998017,0.00002933421,0.00004053262,0.00002318434,0.00004496824,0.00006037403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004268234,0.0001450657,0.00009859559,0.00004660423,0.00001290122,0.0000354595,0.00002339308,0.0000564657,0.9982854,0.00002349772,0.00008049601,0.0007653629],"study_design_scores_gemma":[0.00002848214,0.00152937,0.002209902,0.000006622243,0.00003951926,0.0000637815,0.00003901358,0.0005833357,0.9945363,0.00001397417,0.0009446367,0.000005175491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901057,0.003453248,0.002309447,0.0001911903,0.0002246887,0.00009598537,0.00147666,0.0001965609,0.001946386],"genre_scores_gemma":[0.9865697,0.001970046,0.003443573,0.0001107512,0.00003873936,0.0002339185,0.001479972,0.00004659176,0.006106731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00270686,"threshold_uncertainty_score":0.00538224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02639379936254269,"score_gpt":0.2892621089307751,"score_spread":0.2628683095682324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}