{"id":"W4389726972","doi":"10.1021/jacs.3c10034","title":"Two-Pronged Dormant Photosensitizer-Antibiotic Bacterial Inactivation: Mechanism, Dosage, and Cellular Evolution Visualized at the Single-Cell Level","year":2023,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Chemistry; Singlet oxygen; Reactive oxygen species; Multidrug tolerance; Photosensitizer; Bacteria; Biophysics; Escherichia coli; Antibiotics; Programmed cell death; Bacterial cell structure; Quenching (fluorescence); Cell; Microbiology; Pseudomonas aeruginosa; Autoinducer; Photochemistry; Biochemistry; Oxygen; Apoptosis; Fluorescence; Biofilm; Quorum sensing; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001808232,0.0004552013,0.000453744,0.0001471889,0.0001128612,0.0004523553,0.0002777835,0.0005531695,0.0006403216],"category_scores_gemma":[0.000114662,0.0002500146,0.0001701806,0.00009735221,0.0002790494,0.0003072957,0.000392426,0.0005410466,0.0002080395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002725571,"about_ca_system_score_gemma":0.0001620639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001870793,"about_ca_topic_score_gemma":0.0003702855,"domain_scores_codex":[0.9998512,0.0000193547,0.00001119897,0.00004710106,0.00004778921,0.00002326068],"domain_scores_gemma":[0.9999176,0.00002066254,0.00002857,0.00001292925,0.000007239054,0.00001291784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009503372,0.000006413406,0.00002454047,0.00001464056,0.000001095579,0.00001231987,0.000006040855,0.00004250655,0.9990544,0.00005168779,0.000008807348,0.0007680774],"study_design_scores_gemma":[0.000003662756,0.00009401849,0.000304894,0.000001616555,0.000003294342,0.00007225703,0.000003649019,0.0008494,0.9979264,0.00002404674,0.0007145657,0.000002222112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729493,0.00233398,0.02306218,0.0001276992,0.00004822698,0.00006962849,0.0001378701,0.0001991957,0.001071981],"genre_scores_gemma":[0.9796627,0.0009210348,0.01650885,0.00006205837,0.0000100997,0.00008098438,0.00008784569,0.00004158577,0.00262483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006403216,"threshold_uncertainty_score":0.002142131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01649422048153538,"score_gpt":0.2332290723629811,"score_spread":0.2167348518814457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}