{"id":"W4389727426","doi":"10.1183/13993003.00337-2023","title":"Genome-wide association study of preserved ratio impaired spirometry (PRISm)","year":2023,"lang":"en","type":"review","venue":"European Respiratory Journal","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia; McGill University","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; NIHR Leicester Biomedical Research Centre; National Institutes of Health; ZonMw; University of Leicester; Age UK; National Center for Advancing Translational Sciences; Medical Research Council; Department of Health and Social Care; Novo Nordisk; National Institute on Aging; National Institute for Health and Care Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Biotechnology and Biological Sciences Research Council; Wellcome Trust; European Commission; Broad Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Sanofi; Novo Nordisk Fonden; Genentech; Vlaamse regering; U.S. Environmental Protection Agency; University of Virginia; National Cancer Institute; University of Bristol; Economic and Social Research Council; COPD Foundation; Directorate for Biological Sciences; GlaxoSmithKline; Erasmus Universiteit Rotterdam; AstraZeneca; U.S. Department of Veterans Affairs; Pfizer; Sunovion; Center for Strategic Scientific Initiatives, National Cancer Institute","keywords":"Medicine; Spirometry; Association (psychology); Prism; Genome-wide association study; Genetic association; Internal medicine; Genetics; Asthma; Gene; Genotype; Single-nucleotide polymorphism; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003611234,0.0007872472,0.001003036,0.001180073,0.0006958529,0.0012355,0.0007369042,0.001479228,0.002340338],"category_scores_gemma":[0.008272228,0.0004118673,0.002967344,0.002691918,0.0005103513,0.0003610974,0.0009630412,0.001397033,0.0001996948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003509652,"about_ca_system_score_gemma":0.0005942083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005809066,"about_ca_topic_score_gemma":0.00602154,"domain_scores_codex":[0.996217,0.001674456,0.0003318297,0.001184709,0.0002854319,0.0003067007],"domain_scores_gemma":[0.9937212,0.003557522,0.001210993,0.0006566382,0.0004041998,0.0004494497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002132545,0.00007679262,0.9710121,0.0003358946,0.01663182,0.0006360103,0.0001176564,0.0005030131,0.00192622,0.0002576669,0.0008010841,0.005569191],"study_design_scores_gemma":[0.0001964495,0.0003040855,0.9872427,0.00007157487,0.008778557,0.0005573706,0.00007899574,0.0009938343,0.000311791,0.0004034687,0.00104428,0.00001698066],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9791278,0.01487946,0.001576902,0.000970091,0.0001812449,0.00002452567,0.002168623,0.00005939163,0.001011848],"genre_scores_gemma":[0.9973084,0.001023253,0.0005542633,0.000169296,0.00006168256,0.00001878976,0.0006522145,0.00001133913,0.000200783],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.005809066,"threshold_uncertainty_score":0.01909828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1038345062162927,"score_gpt":0.3623440694353648,"score_spread":0.2585095632190721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}