{"id":"W4389729205","doi":"10.1038/s41586-023-06947-z","title":"Structures, functions and adaptations of the human LINE-1 ORF2 protein","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Common Fund; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of California, San Francisco; Dana-Farber Cancer Institute; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Pharmaron","keywords":"Retrotransposon; Biology; Processivity; RNA; Computational biology; DNA; Translation (biology); Structural biology; Cell biology; DNA replication; Genetics; Genome; Gene; Messenger RNA; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003519236,0.00004220607,0.00004341649,0.000005750834,0.0002623218,0.00001234525,0.00008767156,0.0001944863,0.0001602623],"category_scores_gemma":[0.00004064001,0.00001250962,0.00003208227,0.0004072619,0.0000310633,0.00001780942,0.0000448129,0.0002764461,0.000004689939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002763238,"about_ca_system_score_gemma":0.000005030806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006067642,"about_ca_topic_score_gemma":0.0009160076,"domain_scores_codex":[0.9996594,0.00001963944,0.00006710013,0.00009040975,0.00009542238,0.00006807558],"domain_scores_gemma":[0.9998404,0.00003092768,0.00003085524,0.00003649075,0.00004054939,0.00002078526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000001840021,0.00001815195,0.003433129,0.000004011391,0.00001069632,3.244664e-7,0.00009429936,0.00003106277,0.9652776,0.01686678,0.00146235,0.01279982],"study_design_scores_gemma":[0.00005333469,0.00003733407,0.963299,0.000007992145,0.000008080694,0.000001593125,0.0001514339,0.00004019978,0.00320512,0.01106645,0.02208362,0.00004583538],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941464,0.0001223269,3.162592e-7,0.004675252,0.00007951169,0.0001420276,0.0001098394,0.00003098579,0.0006933616],"genre_scores_gemma":[0.9974987,0.000004748444,0.00002393496,0.00007185378,0.0001187548,0.00001002072,0.00004808448,3.292364e-7,0.002223587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9620724,"threshold_uncertainty_score":0.2017593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794094725715275,"score_gpt":0.2358300986835777,"score_spread":0.217889151426425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}