{"id":"W4389729205","doi":"10.1038/s41586-023-06947-z","title":"Structures, functions and adaptations of the human LINE-1 ORF2 protein","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Common Fund; National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; University of California, San Francisco; Dana-Farber Cancer Institute; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Pharmaron","keywords":"Retrotransposon; Biology; Processivity; RNA; Computational biology; DNA; Translation (biology); Structural biology; Cell biology; DNA replication; Genetics; Genome; Gene; Messenger RNA; Transposable element","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006833582,0.0004238781,0.0001528574,0.0001333073,0.0001807575,0.0002265205,0.0002495706,0.0003351172,0.0007695342],"category_scores_gemma":[0.0001258626,0.0001101739,0.0002428845,0.0001523991,0.0001805659,0.0001709186,0.0001187781,0.0002562668,0.0004919788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003647088,"about_ca_system_score_gemma":0.00008510042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005327145,"about_ca_topic_score_gemma":0.0002912537,"domain_scores_codex":[0.9999608,0.000005546557,0.000002267296,0.00001701765,0.000008325153,0.000006008358],"domain_scores_gemma":[0.9999567,0.000007842564,0.00001534532,0.000004168055,0.000007002635,0.000008880706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005902422,0.00004526573,0.003354688,0.000160913,0.00002734809,0.001224593,0.0001463141,0.002993089,0.9869339,0.0004865197,0.0004376144,0.003599443],"study_design_scores_gemma":[0.0001296312,0.0009503645,0.08198588,0.00004910869,0.0001124584,0.00691869,0.0002882559,0.03894144,0.8521277,0.001520761,0.01690779,0.00006792826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956555,0.002012632,0.001313681,0.00006974392,0.00001166607,0.000006622858,0.0003025943,0.0000368187,0.0005907883],"genre_scores_gemma":[0.9966602,0.0005333798,0.0008540863,0.0000352867,0.00001389403,0.0000100132,0.001197141,0.00001005053,0.0006858674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007695342,"threshold_uncertainty_score":0.002646148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794094725715275,"score_gpt":0.2358300986835777,"score_spread":0.217889151426425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}