{"id":"W4389736151","doi":"10.1038/s41467-023-43510-w","title":"Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Venomous Animal Envenomation and Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"Medical Research Foundation; Wellcome; Royal Society; Medical Research Council; Research Councils UK; Wellcome Trust","keywords":"Cytotoxic T cell; Medicine; Biology; Pharmacology; Computational biology; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009297457,0.0002427891,0.0002463052,0.0003021271,0.00009640025,0.0001728753,0.0002184355,0.0001602462,0.002800525],"category_scores_gemma":[0.00008729831,0.0000619423,0.0002100182,0.000115844,0.0001339631,0.0001520981,0.0001168824,0.0004197696,0.0003633858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00010052,"about_ca_system_score_gemma":0.0001144009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002339649,"about_ca_topic_score_gemma":0.0007169563,"domain_scores_codex":[0.9999434,0.00001632334,0.000004151441,0.000007067768,0.00001750125,0.00001155275],"domain_scores_gemma":[0.9999683,0.000004640446,0.000007863745,0.000003476054,0.000004554981,0.00001116832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00145326,0.0008787115,0.0004619779,0.000398726,0.00005938874,0.0001921437,0.00002934608,0.0003338618,0.9263347,0.0003174192,0.0006225299,0.06891797],"study_design_scores_gemma":[0.000671411,0.02788666,0.03131176,0.0001044938,0.0002888548,0.001796498,0.0001216978,0.001155064,0.9046002,0.0003657905,0.0316771,0.00002040877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972378,0.01816981,0.001796445,0.0003520708,0.0001224084,0.0001669551,0.0002604589,0.0001146364,0.006639156],"genre_scores_gemma":[0.982868,0.01115411,0.001968352,0.0001364927,0.00006441183,0.00005961945,0.0002573048,0.000009686367,0.003481936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002800525,"threshold_uncertainty_score":0.009368658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02114004418743795,"score_gpt":0.2829923194703243,"score_spread":0.2618522752828863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}