{"id":"W4389741250","doi":"10.1038/s41541-023-00786-9","title":"A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax","year":2023,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Malaria Research and Control","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Mahidol University","keywords":"Immunogenicity; Vaccination; Virology; Immunity; Adjuvant; Plasmodium vivax; Antigen; Malaria vaccine; Antibody; Immunology; Medicine; Biology; Immune system; Malaria; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004425149,0.0002238416,0.0004698862,0.0003699035,0.0002844193,0.00006818584,0.0001941368,0.0001025389,0.0005768268],"category_scores_gemma":[0.0005037779,0.0001730491,0.00008099538,0.0007387711,0.00001090805,0.00008431714,0.0001247172,0.0003603003,0.0001613641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003070381,"about_ca_system_score_gemma":0.0001045013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003589487,"about_ca_topic_score_gemma":0.00005588704,"domain_scores_codex":[0.9983192,0.00007945231,0.0003126516,0.0003526824,0.0003545557,0.0005814433],"domain_scores_gemma":[0.9986157,0.000249889,0.00004591924,0.000380263,0.0002105898,0.0004976607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004588303,0.0003241794,0.02797726,0.0008219735,0.0004372528,0.0003525252,0.001417471,0.00007630019,0.8131922,0.0008590132,0.07240852,0.07754496],"study_design_scores_gemma":[0.01266117,0.00175057,0.8268855,0.0006559669,0.0001849699,0.0001358149,0.0008956469,0.006708458,0.02618414,0.001174448,0.1221311,0.0006322284],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686002,0.0004052986,0.0001127609,0.02733802,0.0001529427,0.0007438422,0.00001788854,0.0002461016,0.002382912],"genre_scores_gemma":[0.9953012,0.0002517396,0.0003188866,0.00064137,0.00032425,0.00007547865,0.00003530626,0.00003501664,0.003016678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7989082,"threshold_uncertainty_score":0.7056737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03140822751831229,"score_gpt":0.2965979429239622,"score_spread":0.2651897154056499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}