{"id":"W4389741250","doi":"10.1038/s41541-023-00786-9","title":"A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax","year":2023,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Malaria Research and Control","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; Mahidol University","keywords":"Immunogenicity; Vaccination; Virology; Immunity; Adjuvant; Plasmodium vivax; Antigen; Malaria vaccine; Antibody; Immunology; Medicine; Biology; Immune system; Malaria; Plasmodium falciparum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009933206,0.0003881349,0.0002149703,0.000168779,0.00009679495,0.0001517411,0.0001443252,0.0002007726,0.0008698645],"category_scores_gemma":[0.0001407343,0.0001070826,0.0001776645,0.00007816774,0.0002525262,0.0001667022,0.0001320474,0.0004475353,0.000172764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002252861,"about_ca_system_score_gemma":0.0002146107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000602483,"about_ca_topic_score_gemma":0.0006163667,"domain_scores_codex":[0.9998794,0.00001088096,0.000008948745,0.00002866954,0.00003205445,0.00004005057],"domain_scores_gemma":[0.9999417,0.00001088762,0.00001957715,0.000004758921,0.000008616825,0.00001451849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009024855,0.00003895574,0.00006667826,0.00003686613,0.000003415234,0.00002480361,0.00001209836,0.0002465164,0.9974032,0.00006119208,0.00005186019,0.001964061],"study_design_scores_gemma":[0.00003729483,0.002329849,0.00211162,0.000009786761,0.0000312134,0.0001414901,0.00002000467,0.002029244,0.9904758,0.00004251451,0.00276392,0.000007244902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99541,0.0005550505,0.002577499,0.00005903804,0.00003574628,0.00003849361,0.0001015177,0.00009795326,0.00112471],"genre_scores_gemma":[0.9962703,0.0003771649,0.001512082,0.00005410359,0.00001325969,0.00002871743,0.0002893198,0.000016566,0.001438305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008698645,"threshold_uncertainty_score":0.002910018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03140822751831229,"score_gpt":0.2965979429239622,"score_spread":0.2651897154056499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}