{"id":"W4389752877","doi":"10.1016/s0140-6736(23)01857-3","title":"Standard-of-care systemic therapy with or without stereotactic body radiotherapy in patients with oligoprogressive breast cancer or non-small-cell lung cancer (Consolidative Use of Radiotherapy to Block [CURB] oligoprogression): an open-label, randomised, controlled, phase 2 study","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":255,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; National Institutes of Health; Invitae; Susan G. Komen; Breast Cancer Research Foundation","keywords":"Radiation therapy; Medicine; Cancer; Breast cancer; Lung cancer; Standard of care; Stereotactic radiotherapy; Systemic therapy; Oncology; Radiology; Internal medicine; Radiosurgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002937644,0.0005545616,0.001848756,0.0001299689,0.0001646565,0.000095746,0.0007482622,0.00009781012,0.0000342309],"category_scores_gemma":[0.0000164638,0.0002642682,0.00005439109,0.0006012883,0.0001951152,0.00004409902,0.0001311178,0.000153559,3.51083e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828829,"about_ca_system_score_gemma":0.0005829828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008598168,"about_ca_topic_score_gemma":0.001828444,"domain_scores_codex":[0.9973515,0.0004671418,0.0005485423,0.0006536936,0.0004231011,0.0005560147],"domain_scores_gemma":[0.997525,0.0001307112,0.000658428,0.0009769406,0.0005812365,0.0001277192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5105224,0.001702031,0.4721034,0.0001249869,0.002690264,0.00001792804,0.006674649,0.0003136768,0.002909027,3.47133e-7,0.0002433909,0.002697881],"study_design_scores_gemma":[0.8638367,0.02394638,0.09452201,0.001773364,0.0006137594,0.00002382485,0.004406641,0.0002245377,0.00959644,3.827237e-7,0.0002263751,0.0008295691],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984432,0.003400666,0.0000294239,0.0002257461,0.0001014074,0.01049424,0.001280047,0.00002928882,0.000007196052],"genre_scores_gemma":[0.991172,0.00317089,0.0003916339,0.0002311424,0.0002299303,0.004527744,0.00006259442,0.0001178188,0.00009628064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3775814,"threshold_uncertainty_score":0.9999809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02831244113882767,"score_gpt":0.3527839359596867,"score_spread":0.324471494820859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}