{"id":"W4389752878","doi":"10.1016/s2468-1253(23)00318-7","title":"Efficacy and safety of 48 weeks of guselkumab for patients with Crohn's disease: maintenance results from the phase 2, randomised, double-blind GALAXI-1 trial","year":2023,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; University of Calgary","funders":"Janssen Scientific Affairs; Genentech; Celgene; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Crohn's disease; Medicine; Disease; Internal medicine; Phase (matter); Double blind; Maintenance therapy; Physical therapy; Surgery; Pediatrics; Alternative medicine; Placebo; Pathology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001420149,0.001477364,0.002642932,0.0003071375,0.0003636759,0.001078692,0.0009851059,0.002276748,0.005353991],"category_scores_gemma":[0.001539909,0.0006358339,0.001811199,0.0003004811,0.0009552777,0.001432434,0.0003587245,0.004031547,0.001429309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006634836,"about_ca_system_score_gemma":0.0005319598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006406399,"about_ca_topic_score_gemma":0.001062703,"domain_scores_codex":[0.9994616,0.0002374399,0.00003165542,0.00009081143,0.0000420463,0.0001364066],"domain_scores_gemma":[0.9990845,0.0002888135,0.000232172,0.00009592361,0.00004169612,0.0002569924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9606083,0.002698251,0.0007891366,0.0007070193,0.0008347122,0.00005413762,0.0000637207,0.0003665755,0.004021099,0.00007891505,0.001150321,0.02862777],"study_design_scores_gemma":[0.9359623,0.05435103,0.007155451,0.00006593271,0.000562067,0.00006807003,0.00003715647,0.0003442559,0.000609591,0.0001461748,0.0006715856,0.00002639766],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848979,0.01052197,0.0002821985,0.0008566656,0.0003596839,0.0004155654,0.0009241887,0.0001154992,0.001626249],"genre_scores_gemma":[0.9906325,0.003082287,0.0004994191,0.00106913,0.0003610777,0.0007233617,0.001131479,0.0000272327,0.002473451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005353991,"threshold_uncertainty_score":0.0179109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691190991397384,"score_gpt":0.2681455201592174,"score_spread":0.2512336102452436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}