{"id":"W4389774725","doi":"10.1016/s0140-6736(23)02408-x","title":"Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease: a randomised, controlled, phase 2 trial","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":187,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"Steno Diabetes Center Copenhagen; Boehringer Ingelheim","keywords":"Empagliflozin; Medicine; Aldosterone; Kidney disease; Aldosterone synthase; Randomized controlled trial; Internal medicine; Pharmacology; Endocrinology; Diabetes mellitus; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000470522,0.0000997641,0.0006099748,0.00005038911,0.00007958198,0.00001235999,0.00002404538,0.00003088826,0.00001863847],"category_scores_gemma":[0.0004841002,0.00005248624,0.00004578493,0.00008689971,0.0001202751,0.00003553431,0.00001642693,0.00005964323,0.00000218674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001518213,"about_ca_system_score_gemma":0.0001074879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003138295,"about_ca_topic_score_gemma":0.000003006314,"domain_scores_codex":[0.9992855,0.00005809711,0.0002078874,0.0001441764,0.000160133,0.000144164],"domain_scores_gemma":[0.9992521,0.0002549674,0.00008853784,0.0001850044,0.00005644372,0.0001629921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9820141,0.0001071597,0.0001039157,0.0001334012,0.0001297676,0.000008512113,0.0001182649,0.000007339323,0.008717343,0.0001167867,0.00339891,0.00514453],"study_design_scores_gemma":[0.9815146,0.00135951,0.002896415,0.0003397321,0.0005404364,0.00001803155,0.00002532941,0.006572808,0.0003506405,0.00005438317,0.006255758,0.00007240691],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827335,0.0008031153,0.0002891027,0.0124567,0.00003410707,0.00347487,0.00009572601,0.00004551949,0.00006730221],"genre_scores_gemma":[0.9981385,0.0003507344,0.00006918343,0.0004530379,0.0004723218,0.0001438448,0.0001186642,0.00001475248,0.0002389326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01540497,"threshold_uncertainty_score":0.2140327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03485877958951788,"score_gpt":0.3190192297822023,"score_spread":0.2841604501926844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}