{"id":"W4389778747","doi":"10.1371/journal.pone.0295974","title":"In silico analysis of TRPM4 variants of unknown clinical significance","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Russian Science Foundation","keywords":"Missense mutation; In silico; Genetics; Biology; Computational biology; Clinical significance; Mutation; Bioinformatics; Gene; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001541827,0.0009815595,0.0007973915,0.001130773,0.0004744948,0.0007367324,0.0006045362,0.0008946945,0.002280973],"category_scores_gemma":[0.005143492,0.0002069054,0.001164292,0.0007722541,0.0002154813,0.0002973378,0.0004349262,0.0004301718,0.0007658817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003261794,"about_ca_system_score_gemma":0.000765071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009345711,"about_ca_topic_score_gemma":0.001648459,"domain_scores_codex":[0.9992441,0.0002672761,0.00006715417,0.0002085087,0.000137013,0.00007592869],"domain_scores_gemma":[0.9961364,0.003051628,0.0002599101,0.0001579126,0.0002501212,0.0001439973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.007085225,0.001147897,0.5771402,0.002533805,0.001838819,0.0139726,0.0004200003,0.2200398,0.0821285,0.001806724,0.01672829,0.07515816],"study_design_scores_gemma":[0.0005070177,0.001302387,0.07915294,0.0002135698,0.001230195,0.00878915,0.0003263958,0.8653395,0.03117407,0.002266184,0.009604796,0.00009371158],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745398,0.001372201,0.0142715,0.0002983306,0.0001232907,0.0001329354,0.006008662,0.001776991,0.001476261],"genre_scores_gemma":[0.9654807,0.0002840499,0.01917429,0.0001703647,0.0000355697,0.00006316938,0.01435695,0.0001597706,0.0002751576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002280973,"threshold_uncertainty_score":0.008154035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1913857940206899,"score_gpt":0.3460362721629779,"score_spread":0.154650478142288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}