{"id":"W4389782386","doi":"10.1021/acsomega.3c07070","title":"Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle","year":2023,"lang":"en","type":"article","venue":"ACS Omega","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Canada Research Chairs; Ontario Institute for Cancer Research; York University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto; Peterborough K. M. Hunter Charitable Foundation; Québec Consortium for Drug Discovery; Mitacs; York University","keywords":"Catalysis; Small molecule; Molecule; Chemistry; Computer science; Nanotechnology; Combinatorial chemistry; Materials science; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001856681,0.0001681693,0.0001496971,0.00006276254,0.00008496019,0.00005621414,0.0003312031,0.000173687,0.00001192853],"category_scores_gemma":[0.000118505,0.0001674871,0.0001012006,0.000225806,0.00008527268,0.000004589102,0.0003198886,0.0001078195,0.0006173705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009339224,"about_ca_system_score_gemma":0.00005331669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003696899,"about_ca_topic_score_gemma":0.0000190478,"domain_scores_codex":[0.9988995,0.00002270448,0.000177573,0.0003873383,0.0001389651,0.0003738826],"domain_scores_gemma":[0.9993166,0.00001559918,0.00004888848,0.0004479795,0.00005798526,0.0001129361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002807635,0.00002675805,0.0003761565,0.00002681773,0.00004102294,0.00001455132,0.00005207408,0.000003765646,0.9879239,0.00005054798,0.01079913,0.0006571622],"study_design_scores_gemma":[0.0004131569,0.00007519257,0.0006656171,0.00001735458,0.00001561439,0.00001198376,0.00004654158,0.00005699364,0.9884472,0.0002048434,0.009822416,0.0002230855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993516,0.0003664991,0.0001490059,0.0001907174,0.0001326921,0.0001948615,0.00004795826,0.00006573168,0.005336497],"genre_scores_gemma":[0.9920121,0.0001092422,0.000146233,0.0002696585,0.0003045598,0.0000539689,0.000621222,0.0000370593,0.006445913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503894,"threshold_uncertainty_score":0.7935255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02467527181303654,"score_gpt":0.2494773179041418,"score_spread":0.2248020460911053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}