{"id":"W4389791812","doi":"10.3389/ti.2023.11845","title":"Isavuconazole for Treating Invasive Mould Disease in Solid Organ Transplant Recipients","year":2023,"lang":"en","type":"article","venue":"Transplant International","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Infectious Diseases Centre; University Health Network","funders":"","keywords":"Posaconazole; Medicine; Voriconazole; Adverse effect; Discontinuation; Tacrolimus; Internal medicine; Therapeutic drug monitoring; Itraconazole; Drug; Organ transplantation; Aspergillosis; Azole; Pharmacology; Broad spectrum; Everolimus; Intensive care medicine; Transplantation; Antifungal; Immunology; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002003204,0.0001480662,0.0002246931,0.0001907027,0.0000584963,0.00001678661,0.0001389483,0.00006761367,0.0002346366],"category_scores_gemma":[0.00009503624,0.0001333002,0.0001426505,0.0001737327,0.00004251188,0.0001041957,0.000007312684,0.0001412432,0.00007824152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001009562,"about_ca_system_score_gemma":0.0001405778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005616518,"about_ca_topic_score_gemma":0.0004312854,"domain_scores_codex":[0.9986726,0.00001940308,0.0003554813,0.0003303276,0.0003347537,0.0002874533],"domain_scores_gemma":[0.9993541,0.0002201099,0.00004551465,0.0001422631,0.00008690772,0.0001511439],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003123108,0.0002468663,0.9720196,0.0002048624,0.00009401658,0.0003640405,0.001582254,0.0001168787,0.02014487,0.000663957,0.0003289209,0.001110611],"study_design_scores_gemma":[0.003332177,0.0001042265,0.9810134,0.0009507097,0.00008944795,0.0000133364,0.0001381788,0.0044934,0.008599932,0.0006526147,0.0004141306,0.000198495],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941394,0.00003134682,0.0008182147,0.00189523,0.0003017514,0.0004591598,0.001207193,0.00009107825,0.001056604],"genre_scores_gemma":[0.9949278,0.0003218851,0.0001307862,0.0002650058,0.0001400339,0.00008156204,0.001893918,0.00002187222,0.002217115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01154493,"threshold_uncertainty_score":0.5435823,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03213439206712776,"score_gpt":0.3242839929525751,"score_spread":0.2921496008854473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}