{"id":"W4389793820","doi":"10.1038/s41467-023-44016-1","title":"Identification of 5-HT2A receptor signaling pathways associated with psychedelic potential","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"National Institute of General Medical Sciences; National Institute on Drug Abuse; NIH Clinical Center; National Institutes of Health","keywords":"Receptor; Arrestin; Neuroscience; Serotonergic; 5-HT receptor; Chemistry; Signal transduction; Pharmacology; Tachyphylaxis; Serotonin; G protein-coupled receptor; Cell biology; Psychology; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008610322,0.000267219,0.0001612472,0.000210789,0.00008957046,0.000194521,0.0001060565,0.0002092942,0.00192153],"category_scores_gemma":[0.00005833842,0.00007755866,0.0001664227,0.00008347796,0.0001767644,0.0001216931,0.0001156986,0.000324395,0.0002052627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577197,"about_ca_system_score_gemma":0.0001021595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000388004,"about_ca_topic_score_gemma":0.0008793536,"domain_scores_codex":[0.9999535,0.000006884718,0.000003071888,0.000009791915,0.00001194756,0.00001477299],"domain_scores_gemma":[0.9999465,0.000006033042,0.00002300791,0.000003467287,0.000004448961,0.00001657303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001280076,0.000009998293,0.0002994337,0.00002320477,0.000002728123,0.00003340258,0.000003906656,0.00002638929,0.9985178,0.00006063973,0.00002117149,0.0008733378],"study_design_scores_gemma":[0.00003089523,0.001123587,0.08235916,0.00002068124,0.00003265203,0.000780475,0.00006327342,0.001161926,0.9123338,0.0001383873,0.001944287,0.00001086806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945707,0.001405055,0.001857231,0.0001028852,0.00001282521,0.00002689722,0.0005310207,0.00005100535,0.001442397],"genre_scores_gemma":[0.9963019,0.00106049,0.0009413317,0.00009238278,0.000007297427,0.00002739989,0.000459703,0.000005553443,0.001104069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00192153,"threshold_uncertainty_score":0.006428182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05433153584288993,"score_gpt":0.3571352222172753,"score_spread":0.3028036863743854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}