{"id":"W4389794367","doi":"10.1038/s41375-023-02107-4","title":"DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML","year":2023,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec; Princess Margaret Cancer Centre; Centre Hospitalier Universitaire Sainte-Justine; Hôpital Maisonneuve-Rosemont; Université de Montréal; University of Toronto; University Health Network; Institute for Research in Immunology and Cancer","funders":"Institut de Valorisation des Données; Canada First Research Excellence Fund; Université de Montréal; Government of Canada; Génome Québec; Compute Canada; Canadian Institutes of Health Research; Genome Canada","keywords":"Haploinsufficiency; Biology; Cancer research; Myeloid leukemia; Monosomy; Genetics; Transcriptome; Chromosome 7 (human); Leukemia; Gene; Chromosome; Phenotype; Gene expression; Karyotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003419613,0.0004000691,0.0006658914,0.001006357,0.0001734069,0.00007699997,0.0005773299,0.000328179,0.0001419554],"category_scores_gemma":[0.001241693,0.0003831974,0.00016317,0.003367266,0.00009859999,0.0001949023,0.0003277082,0.0009115657,0.00169276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003264978,"about_ca_system_score_gemma":0.001807617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001248117,"about_ca_topic_score_gemma":0.001296112,"domain_scores_codex":[0.9958732,0.0001316939,0.0006843101,0.0009771551,0.001034441,0.001299189],"domain_scores_gemma":[0.9977201,0.0003302002,0.00009994634,0.00106351,0.0002190383,0.0005672601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002788404,0.0004192979,0.0252631,0.0006153275,0.0001866356,0.001547659,0.004164908,0.00137125,0.745665,0.001129865,0.2108068,0.006041707],"study_design_scores_gemma":[0.01887844,0.001713476,0.2070332,0.00224228,0.0002244474,0.00006070751,0.003867649,0.005657882,0.6851225,0.0007163613,0.07212421,0.002358758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885855,0.0001014115,0.0001005422,0.003651318,0.0005018511,0.001297745,0.0000595482,0.0004569995,0.005245134],"genre_scores_gemma":[0.9859674,0.0001273126,0.001843413,0.0009016804,0.0007261278,0.0003518467,0.00009233405,0.0001169386,0.009872972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1817701,"threshold_uncertainty_score":0.999862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03124381591636909,"score_gpt":0.3105839742521713,"score_spread":0.2793401583358022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}