{"id":"W4389794710","doi":"10.21203/rs.3.rs-3701293/v1","title":"A phase 2 trial of peri-operative avelumab and chemotherapy for locally advanced gastro-esophageal adenocarcinoma: Association of AGR2/AP-1 complex CD8 T-cells and M2-Tumour Associated Macrophages with treatment response","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Fondation de l'Hôpital Général de Montréal; U.S. Army Medical Research Acquisition Activity; EMD Serono; McGill University Health Centre; Merck KGaA","keywords":"Avelumab; Medicine; Neoadjuvant therapy; Docetaxel; Oncology; Adenocarcinoma; Immunotherapy; CD8; Internal medicine; Chemotherapy; Nivolumab; Cancer research; Immune system; Immunology; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001493282,0.001237255,0.001591415,0.0002739065,0.0002762279,0.0009540856,0.0005638341,0.001214299,0.004028885],"category_scores_gemma":[0.001072064,0.0004742004,0.001128109,0.0002207909,0.001048903,0.0008148258,0.0002987088,0.002954774,0.0007910538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006780658,"about_ca_system_score_gemma":0.0009238779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005306807,"about_ca_topic_score_gemma":0.001309949,"domain_scores_codex":[0.9995998,0.0002055431,0.00001277312,0.00006902227,0.00002822855,0.00008466639],"domain_scores_gemma":[0.9992937,0.0002019008,0.00009589367,0.0000948157,0.00003028314,0.0002833742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9304562,0.02028503,0.002627855,0.000177493,0.0005619163,0.00007788151,0.00007191995,0.0007087621,0.01660991,0.0001062513,0.001299874,0.02701693],"study_design_scores_gemma":[0.5778979,0.3974147,0.01478764,0.00002250247,0.0005338296,0.0002341884,0.00006366158,0.001530191,0.00497906,0.0003159161,0.002187026,0.00003327671],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970591,0.0006488893,0.0001945974,0.0003697993,0.0001341677,0.0003753508,0.0005026633,0.00004380255,0.0006716333],"genre_scores_gemma":[0.9905602,0.0006187063,0.001151842,0.0007100854,0.0002242467,0.000917564,0.001761088,0.00002991291,0.004026278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004028885,"threshold_uncertainty_score":0.01347798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06037865044308741,"score_gpt":0.404917345697739,"score_spread":0.3445386952546516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}