{"id":"W4389794786","doi":"10.3390/ijms242417525","title":"In Vitro and In Vivo Evidence towards Fibronectin’s Protective Effects against Prion Infection","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Alberta Prion Research Institute; Universidad de Zaragoza","keywords":"Scrapie; Extracellular matrix; Fibronectin; Biology; Extracellular; In vitro; C2C12; Infectivity; Myogenesis; Cell biology; Cell culture; Gene isoform; Virology; Myocyte; Prion protein; Virus; Genetics; Gene; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003603307,0.000462492,0.0001794927,0.0002441434,0.000163748,0.0002126828,0.0002394443,0.0003429472,0.001768727],"category_scores_gemma":[0.0002920144,0.0001241397,0.0002207551,0.0001258693,0.0002490197,0.0001263204,0.0001251103,0.0004574258,0.0003559683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631438,"about_ca_system_score_gemma":0.0001206486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002018099,"about_ca_topic_score_gemma":0.002460135,"domain_scores_codex":[0.999754,0.00008891282,0.00002135524,0.00002933113,0.00005429127,0.00005203857],"domain_scores_gemma":[0.9996238,0.0001551142,0.00005004067,0.00006054056,0.00005951495,0.00005104165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009764916,0.00003235053,0.0001400214,0.00005504354,0.000004540144,0.00006738219,0.00001531825,0.0000224487,0.9990301,0.00002525664,0.00003024265,0.0004797235],"study_design_scores_gemma":[0.000017564,0.00136207,0.01496619,0.00001943435,0.00004000254,0.0005845844,0.00005339563,0.0005734891,0.9798994,0.00006420467,0.002413387,0.000006408444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839935,0.005497837,0.004040664,0.0001606166,0.00007908765,0.00003556888,0.0005114965,0.00006381453,0.005617426],"genre_scores_gemma":[0.9900656,0.002000383,0.003349829,0.0001135407,0.00005156799,0.00003445662,0.001015429,0.00001613567,0.003353076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002018099,"threshold_uncertainty_score":0.005917013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01366280333088291,"score_gpt":0.3106539162963507,"score_spread":0.2969911129654678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}