{"id":"W4389794919","doi":"10.3390/ijms242417535","title":"OncoTherad® (MRB-CFI-1) Nanoimmunotherapy: A Promising Strategy to Treat Bacillus Calmette–Guérin-Unresponsive Non-Muscle-Invasive Bladder Cancer: Crosstalk among T-Cell CX3CR1, Immune Checkpoints, and the Toll-Like Receptor 4 Signaling Pathway","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Bladder cancer; Crosstalk; Immune system; Toll-like receptor; Cancer research; Receptor; Medicine; Biology; Immunology; Cancer; Innate immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950603,0.0002056765,0.0003521595,0.0001920685,0.00008771871,0.0001905199,0.0001587545,0.0002011021,0.0006232543],"category_scores_gemma":[0.0000655446,0.00006739273,0.0002217568,0.0001058602,0.000138393,0.0001868171,0.000124534,0.0003843351,0.0001017011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032308,"about_ca_system_score_gemma":0.0001583921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001893885,"about_ca_topic_score_gemma":0.0005405837,"domain_scores_codex":[0.9999367,0.00001454958,0.000003352607,0.00001388147,0.00001406213,0.00001745628],"domain_scores_gemma":[0.9999695,0.000005257769,0.00001098445,0.00000310259,0.000002685974,0.000008477945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005750385,0.003546792,0.00492047,0.000791051,0.0001391198,0.000226976,0.0001174076,0.001197079,0.730705,0.0005801168,0.0007216049,0.251304],"study_design_scores_gemma":[0.008144353,0.1911526,0.07154044,0.0002420283,0.0007346502,0.00452401,0.0002708254,0.007427903,0.678165,0.000541932,0.03717916,0.00007726538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919639,0.006045933,0.001006076,0.0001006615,0.00003527624,0.00008044059,0.00004473476,0.00003201443,0.0006910235],"genre_scores_gemma":[0.9967519,0.00175138,0.0006762138,0.00008980845,0.00001835367,0.00005819482,0.00010869,0.000003537848,0.0005420036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006232543,"threshold_uncertainty_score":0.00208497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01661235574157155,"score_gpt":0.2973582223808079,"score_spread":0.2807458666392363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}