{"id":"W4389802458","doi":"10.2217/fvl-2023-0146","title":"Resistance Analysis Following Sotrovimab Treatment in Participants with COVID-19 During the Phase III COMET-ICE Study","year":2023,"lang":"en","type":"article","venue":"Future Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"Vir Biotechnology; Janssen Biotech; Otsuka America; Teva Pharmaceutical Industries","keywords":"Epitope; Monoclonal antibody; Clinical endpoint; Coronavirus disease 2019 (COVID-19); Monoclonal; Antibody; Medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Disease; Internal medicine; Immunology; Clinical trial; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007158522,0.0002406667,0.0007117797,0.0007360083,0.0002863335,0.0000254712,0.0002273238,0.0001128104,0.00002601426],"category_scores_gemma":[0.0001768986,0.0001431062,0.0001892367,0.003209517,0.0001106727,0.00005422402,0.00008334625,0.0003053073,0.00005018511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003985197,"about_ca_system_score_gemma":0.000337948,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000775422,"about_ca_topic_score_gemma":0.02121051,"domain_scores_codex":[0.9974921,0.000369689,0.0003499749,0.0005809414,0.0004424134,0.0007649118],"domain_scores_gemma":[0.9986206,0.0004267763,0.00008315712,0.0007277352,0.00003314795,0.0001086029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009782189,0.00182153,0.9539388,0.00006279481,0.003398582,0.007674311,0.01207492,0.0000974569,0.01055339,0.00003569489,0.0001735762,0.0003866928],"study_design_scores_gemma":[0.06822812,0.00457598,0.7817312,0.00002215768,0.003880408,0.00003148234,0.02103729,0.0009314965,0.002420075,0.00005235978,0.1166359,0.0004534738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939206,0.0003996515,0.00005155678,0.004131677,0.0001154662,0.001056165,0.00001158345,0.0001280421,0.0001852595],"genre_scores_gemma":[0.9897917,0.00001096672,0.00001988142,0.009079249,0.0002264795,0.0004765808,0.00001133201,0.00002598024,0.0003578548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1722076,"threshold_uncertainty_score":0.9966499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05125393354423308,"score_gpt":0.4041541427341006,"score_spread":0.3529002091898675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}