{"id":"W4389802458","doi":"10.2217/fvl-2023-0146","title":"Resistance Analysis Following Sotrovimab Treatment in Participants with COVID-19 During the Phase III COMET-ICE Study","year":2023,"lang":"en","type":"article","venue":"Future Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"William Osler Health System","funders":"Vir Biotechnology; Janssen Biotech; Otsuka America; Teva Pharmaceutical Industries","keywords":"Epitope; Monoclonal antibody; Clinical endpoint; Coronavirus disease 2019 (COVID-19); Monoclonal; Antibody; Medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Disease; Internal medicine; Immunology; Clinical trial; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002468561,0.0002934789,0.0006481749,0.0003118514,0.0003476584,0.0007182436,0.0003860765,0.0007437203,0.001653298],"category_scores_gemma":[0.004368894,0.0001660746,0.0008007479,0.0003275056,0.0001415183,0.0003520033,0.0002523883,0.0009015292,0.0003194962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003974813,"about_ca_system_score_gemma":0.000340742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008424416,"about_ca_topic_score_gemma":0.0009500667,"domain_scores_codex":[0.9986351,0.0004644697,0.0001066353,0.0002825309,0.0003317412,0.0001794485],"domain_scores_gemma":[0.9978326,0.0003788427,0.000880765,0.0002009868,0.0004052131,0.000301584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02698785,0.001154495,0.9187262,0.0002147045,0.001061713,0.0003409518,0.000410961,0.0003393086,0.01165552,0.0001551879,0.001886043,0.03706701],"study_design_scores_gemma":[0.0009917989,0.01087824,0.9796799,0.00005299299,0.0005566184,0.000882354,0.0001619834,0.0009849397,0.002424236,0.000124473,0.003239396,0.00002309464],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956327,0.001046915,0.000336884,0.0001376601,0.00003622162,0.0001906567,0.001111004,0.00002514522,0.001482837],"genre_scores_gemma":[0.9980524,0.0001411961,0.0001939219,0.0001467096,0.00002271996,0.00008530266,0.0009048328,0.000006697542,0.0004463019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002468561,"threshold_uncertainty_score":0.01305515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05125393354423308,"score_gpt":0.4041541427341006,"score_spread":0.3529002091898675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}