{"id":"W4389816721","doi":"10.1158/1078-0432.c.6982800","title":"Data from Comprehensive Single-Cell Immune Profiling Defines the Patient Multiple Myeloma Microenvironment Following Oncolytic Virus Therapy in a Phase Ib Trial","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Medicine; Multiple myeloma; Oncolytic virus; Immune system; Flow cytometry; Cytokine; Aldesleukin; Dexamethasone; Bone marrow; Internal medicine; Immunology; Gastroenterology; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002846194,0.0005224145,0.00112656,0.0002295172,0.0003837803,0.001440222,0.0004484284,0.0007061713,0.003108688],"category_scores_gemma":[0.001500261,0.0002430479,0.0007781223,0.000473892,0.000406834,0.0007690372,0.0003531311,0.001813532,0.0008097636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007659898,"about_ca_system_score_gemma":0.001275663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000507738,"about_ca_topic_score_gemma":0.001471924,"domain_scores_codex":[0.9991359,0.0003844369,0.00006450561,0.0001355329,0.000163199,0.0001164582],"domain_scores_gemma":[0.9988181,0.000177583,0.0003374392,0.0002112655,0.0001397485,0.0003158022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3845603,0.01861805,0.07167021,0.001479922,0.003177431,0.0003010739,0.0005014461,0.006516187,0.1894684,0.001250516,0.03653403,0.2859224],"study_design_scores_gemma":[0.1682047,0.3972196,0.2734091,0.0004349868,0.003922692,0.001755948,0.0003878239,0.005882944,0.06454221,0.002393016,0.08169122,0.0001557907],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655082,0.005438529,0.00281226,0.001084361,0.0001837972,0.003596795,0.01043248,0.000198694,0.01074492],"genre_scores_gemma":[0.9751034,0.001605869,0.002667328,0.001618776,0.00009847662,0.003494403,0.01261673,0.00007201544,0.002722992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003108688,"threshold_uncertainty_score":0.01505232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1136096128730226,"score_gpt":0.3447854742209641,"score_spread":0.2311758613479414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}