{"id":"W4389832070","doi":"10.1038/s41420-023-01754-x","title":"The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma","year":2023,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; CIHR Skin Research Training Centre; Cancer Research Society","keywords":"Ubiquitin ligase; Cyclin-dependent kinase; Biology; Ubiquitin; Cyclin D; Cell biology; Cyclin A; Molecular biology; Biochemistry; Cell cycle; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008175871,0.0002435176,0.0002343219,0.0002033449,0.0001327026,0.0001619684,0.0001308488,0.0001212678,0.0009177033],"category_scores_gemma":[0.00008507778,0.0001164558,0.0001975974,0.0001063074,0.0001022165,0.0001193993,0.0001168362,0.0002831074,0.0002936907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002267993,"about_ca_system_score_gemma":0.0001379484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005504807,"about_ca_topic_score_gemma":0.001031423,"domain_scores_codex":[0.9999357,0.00001276918,0.000007128842,0.00001147057,0.00001732115,0.00001561463],"domain_scores_gemma":[0.9999595,0.000006540289,0.0000122941,0.000005357484,0.000004316111,0.00001201157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001237714,0.00002091768,0.0001680755,0.00002668394,0.000006455076,0.00005040567,0.000004999559,0.0001461154,0.9973864,0.0001052223,0.00006719528,0.00189376],"study_design_scores_gemma":[0.0000304775,0.0003512219,0.002525416,0.000003249445,0.00001249857,0.0002432339,0.000007047233,0.001057483,0.9939222,0.00003295146,0.001811278,0.000003030908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920066,0.003329886,0.001944074,0.00009993483,0.00001556288,0.0000217843,0.0002121366,0.0001580999,0.002211955],"genre_scores_gemma":[0.9975815,0.0006093654,0.0009420922,0.00001454742,0.000002608189,0.00000891994,0.0001129625,0.000008490947,0.0007194147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009177033,"threshold_uncertainty_score":0.003069997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212504908817851,"score_gpt":0.2397249057210686,"score_spread":0.2275998566328901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}