{"id":"W4389832070","doi":"10.1038/s41420-023-01754-x","title":"The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma","year":2023,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; CIHR Skin Research Training Centre; Cancer Research Society","keywords":"Ubiquitin ligase; Cyclin-dependent kinase; Biology; Ubiquitin; Cyclin D; Cell biology; Cyclin A; Molecular biology; Biochemistry; Cell cycle; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002748826,0.0001967981,0.0001253755,0.00009580039,0.0002060305,0.0001557944,0.0002169221,0.0001635864,0.00001203287],"category_scores_gemma":[0.0001600266,0.0001548368,0.000130347,0.0003024129,0.00006810192,0.00003237311,0.0001496404,0.0001446526,0.0001731636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003422332,"about_ca_system_score_gemma":0.0001325256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004980579,"about_ca_topic_score_gemma":0.00009091068,"domain_scores_codex":[0.9986568,0.0001129881,0.0002560375,0.0004110223,0.0002217033,0.0003414535],"domain_scores_gemma":[0.9993065,0.00003808547,0.00009731139,0.0004465945,0.00003813207,0.00007335612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001198183,0.0001355273,0.01078889,0.00003118422,0.00003825172,0.00003048551,0.00006215441,0.00009443347,0.9769581,0.0008431869,0.008158424,0.002739562],"study_design_scores_gemma":[0.0006061613,0.0001865851,0.006380865,0.00003047939,0.00001603173,0.000007443264,0.000282588,0.0001309239,0.9539083,0.0005625129,0.0376224,0.0002656619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935793,0.0009491933,0.0006588426,0.0005232825,0.0004685106,0.0004499854,0.00002521795,0.00004543632,0.003300223],"genre_scores_gemma":[0.9840212,0.0004571754,0.00007064983,0.0002003794,0.0001828996,0.0001572255,0.0005901113,0.00003449806,0.0142859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02946398,"threshold_uncertainty_score":0.6314061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212504908817851,"score_gpt":0.2397249057210686,"score_spread":0.2275998566328901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}