{"id":"W4389849063","doi":"10.1101/2023.12.15.571924","title":"Hybrid adaptation is hampered by Haldane’s sieve","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; PROTEO","funders":"","keywords":"Biology; Hybrid; Genetics; Adaptation (eye); Loss of heterozygosity; Fixation (population genetics); Dominance (genetics); Genetic architecture; Gene; Genotype; Allele; Phenotype; Evolutionary biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002407367,0.0002869564,0.0003556993,0.0003517099,0.0002582882,0.0005127268,0.0003371556,0.0004293118,0.001830195],"category_scores_gemma":[0.000537058,0.0002916063,0.0002859873,0.000184875,0.0004603945,0.0003358167,0.0008158875,0.0006996132,0.0003642699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002552251,"about_ca_system_score_gemma":0.0001225807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003410184,"about_ca_topic_score_gemma":0.0005664342,"domain_scores_codex":[0.9998482,0.00002572746,0.0000117887,0.00004051511,0.00004846416,0.00002523281],"domain_scores_gemma":[0.9995914,0.0001222157,0.0001216868,0.00007986333,0.00002651291,0.00005834908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00006527785,0.00001106791,0.0008820159,0.0000277791,0.00001695563,0.0002432655,0.00005487084,0.0006105343,0.9934739,0.0009143014,0.00008272373,0.003617346],"study_design_scores_gemma":[0.00001376599,0.0001434192,0.01072303,0.00001201901,0.00002015491,0.001232714,0.00008364555,0.008349928,0.9718087,0.001327828,0.006254874,0.00002984657],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875985,0.0004100974,0.009429078,0.00009379401,0.00002437624,0.00001010782,0.00009322906,0.0002479587,0.002092941],"genre_scores_gemma":[0.9957418,0.0001121338,0.002603692,0.00004397399,0.000003415836,0.0000127854,0.00007349564,0.00008126991,0.001327488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001830195,"threshold_uncertainty_score":0.006122589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01354152526990988,"score_gpt":0.2215005432798749,"score_spread":0.207959018009965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}