{"id":"W4389849681","doi":"10.1101/2023.12.15.571715","title":"Aging-Dependent Loss of Connectivity in Alzheimer’s Model Mice with Rescue by mGluR5 Modulator","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institutes of Health; Yale University","keywords":"Neuroscience; Default mode network; Alzheimer's disease; Functional connectivity; Medicine; Disease; Psychology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002491083,0.000790164,0.0004955114,0.0007070185,0.0002585215,0.0002571977,0.000346536,0.000553578,0.00207649],"category_scores_gemma":[0.0001213531,0.0002154719,0.0005259243,0.0002302379,0.0004019781,0.0003681158,0.000220925,0.001283889,0.0003821577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003540082,"about_ca_system_score_gemma":0.0002181131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001325618,"about_ca_topic_score_gemma":0.002183943,"domain_scores_codex":[0.9998241,0.0000186441,0.00002380413,0.00005173664,0.00003757619,0.00004411579],"domain_scores_gemma":[0.9997603,0.00001449172,0.00008877832,0.00001930453,0.00002622653,0.00009092482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003020718,0.0001867934,0.0002594288,0.00002955831,0.0000140309,0.00009416987,0.00003541967,0.00005662548,0.9976133,0.00007266107,0.0001317422,0.001204169],"study_design_scores_gemma":[0.0001194442,0.004169348,0.01892719,0.00001696627,0.0001044144,0.0006766775,0.0001072658,0.001713137,0.9714999,0.000251643,0.002394123,0.00001998953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937235,0.0007101844,0.002523639,0.0001783098,0.00005885808,0.00005382106,0.001579211,0.0001975953,0.0009748124],"genre_scores_gemma":[0.9864063,0.0008208695,0.004490922,0.0001975797,0.00002758308,0.0003325275,0.001636926,0.00008637243,0.006000775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00207649,"threshold_uncertainty_score":0.006946504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04373698963912262,"score_gpt":0.2512589284731626,"score_spread":0.20752193883404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}