{"id":"W4389866816","doi":"10.1016/j.msard.2023.105288","title":"Effect of Evobrutinib, a Bruton's Tyrosine Kinase Inhibitor, on Patient-Reported Vitality and Mental Health in Patients with Relapsing Multiple Sclerosis in a Phase 2 Trial","year":2023,"lang":"en","type":"article","venue":"Multiple Sclerosis and Related Disorders","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"NeuroRx Research (Canada)","funders":"","keywords":"Medicine; Multiple sclerosis; Vitality; Internal medicine; Mental health; Tyrosine kinase; Oncology; Psychiatry; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001079838,0.001078963,0.001948843,0.0002103936,0.0003289648,0.0007896106,0.0005052685,0.0009624963,0.002681633],"category_scores_gemma":[0.001073722,0.0002821459,0.00133253,0.0002712818,0.0004894112,0.0006477102,0.0002283444,0.003133446,0.0003560951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005244223,"about_ca_system_score_gemma":0.0005507804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007902511,"about_ca_topic_score_gemma":0.002540733,"domain_scores_codex":[0.9997054,0.0001465878,0.00001568613,0.00003901521,0.00001952615,0.00007366465],"domain_scores_gemma":[0.9995677,0.0001340162,0.00007368605,0.00002164644,0.00002944162,0.0001735508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8799251,0.009543523,0.00417245,0.001257839,0.003337521,0.000160226,0.0001625492,0.001542855,0.007644854,0.0002913685,0.003672089,0.08828969],"study_design_scores_gemma":[0.848457,0.1249841,0.0191674,0.0001329626,0.001492516,0.0002167379,0.0000988758,0.001366073,0.001103602,0.000404997,0.002535909,0.00003986943],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891028,0.007013052,0.000167395,0.0006127788,0.0002245553,0.0003656635,0.0006076432,0.00006034425,0.001845767],"genre_scores_gemma":[0.9933603,0.002693997,0.0003546192,0.0007540178,0.0001679026,0.0005310731,0.000872287,0.00001205637,0.001253637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002681633,"threshold_uncertainty_score":0.008970976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02220395050752715,"score_gpt":0.2817896169211643,"score_spread":0.2595856664136371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}