{"id":"W4389870379","doi":"10.1142/9789811286421_0045","title":"Lymphocyte Count Derived Polygenic Score and Interindividual Variability in CD4 T-cell Recovery in Response to Antiretroviral Therapy","year":2023,"lang":"en","type":"article","venue":"","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Perelman School of Medicine, University of Pennsylvania; University of Pennsylvania Health System; National Center for Research Resources; University of Pennsylvania; Georgia Clinical and Translational Science Alliance; GlaxoSmithKline; Public Health Agency; National Center for Advancing Translational Sciences; ACT Government; National Institutes of Health; Public Health Agency of Canada; Regeneron Pharmaceuticals; Gilead Sciences; Bristol-Myers Squibb","keywords":"Antiretroviral therapy; Population; Univariate; Demography; Medicine; Biology; Immunology; Internal medicine; Human immunodeficiency virus (HIV); Viral load; Multivariate statistics; Statistics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007110574,0.0005889306,0.0006560167,0.0007999087,0.0003677786,0.0009857147,0.0004726039,0.000646382,0.001782179],"category_scores_gemma":[0.01200261,0.0002259313,0.001654591,0.001333832,0.0005192021,0.0004997782,0.0008992725,0.0010354,0.0002436509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002656651,"about_ca_system_score_gemma":0.0003030329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004827694,"about_ca_topic_score_gemma":0.004192697,"domain_scores_codex":[0.9962704,0.002543693,0.0001527458,0.0006324375,0.0001982242,0.0002025325],"domain_scores_gemma":[0.9851189,0.01065635,0.001859972,0.001533672,0.0003856022,0.0004454758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008427325,0.00006701655,0.9823337,0.00002646028,0.002006933,0.00009870985,0.0001386256,0.006084397,0.0007209944,0.0001744005,0.0002341984,0.00727182],"study_design_scores_gemma":[0.00002693619,0.0003128695,0.9593865,0.00001557011,0.0004882199,0.0001980466,0.00008459201,0.03832734,0.0002184723,0.0006942915,0.0002238785,0.00002312302],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966826,0.0001826494,0.002243396,0.00006445002,0.000006769907,0.000009134544,0.0005528695,0.00002780698,0.000230215],"genre_scores_gemma":[0.998931,0.00003252426,0.0004592624,0.00001335776,0.000005750911,0.000008153777,0.0004547439,0.000006370865,0.00008892778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007110574,"threshold_uncertainty_score":0.03760481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02207403114409949,"score_gpt":0.2708016423682966,"score_spread":0.2487276112241971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}