{"id":"W4389870627","doi":"10.1016/j.intimp.2023.111350","title":"TDP43/HDAC6/Prdx1 signaling pathway participated in the cognitive impairment of obstructive sleep apnea via regulating inflammation and oxidative stress","year":2023,"lang":"en","type":"article","venue":"International Immunopharmacology","topic":"Obstructive Sleep Apnea Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Key Clinical Specialty Discipline Construction Program of China; Natural Science Foundation of Hunan Province; National Natural Science Foundation of China","keywords":"Oxidative stress; Obstructive sleep apnea; Medicine; Neuroinflammation; Inflammation; Internal medicine; Polysomnography; HDAC6; Montreal Cognitive Assessment; Sleep apnea; Endocrinology; Immunology; Gastroenterology; Histone deacetylase; Cognitive impairment; Apnea; Histone; Biology; Biochemistry; Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002625207,0.0007606322,0.0006722612,0.0004289393,0.0005220314,0.000597865,0.0003850609,0.0004376639,0.001635488],"category_scores_gemma":[0.0001958778,0.000294009,0.0009268298,0.0002749688,0.000496109,0.0004244128,0.0006099455,0.001042341,0.000177421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004365322,"about_ca_system_score_gemma":0.0007313288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002694259,"about_ca_topic_score_gemma":0.003511365,"domain_scores_codex":[0.9997571,0.00002968082,0.00002429813,0.00005978168,0.00004687411,0.00008232878],"domain_scores_gemma":[0.9999086,0.000004009961,0.00003264541,0.000007532492,0.00002072235,0.00002653534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007376952,0.0007627085,0.06760796,0.001661526,0.001186,0.00418342,0.000727869,0.0007291342,0.8526472,0.002874937,0.002942154,0.05730003],"study_design_scores_gemma":[0.0006541317,0.001969262,0.6096999,0.0002331214,0.00287161,0.004966466,0.001685703,0.005612753,0.3436519,0.004713395,0.02380762,0.000134117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651428,0.02439399,0.004512365,0.0009570247,0.0004110147,0.00006747131,0.001001575,0.0001545925,0.003359226],"genre_scores_gemma":[0.9902139,0.005306995,0.001086942,0.0001539006,0.00006462065,0.0000466881,0.0004288652,0.0000122902,0.002685814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002694259,"threshold_uncertainty_score":0.005471289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02942121494243175,"score_gpt":0.348296741355528,"score_spread":0.3188755264130962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}