{"id":"W4389883521","doi":"10.1080/19490976.2023.2293170","title":"Cytolethal distending toxin B inoculation leads to distinct gut microtypes and IBS-D-like microRNA-mediated gene expression changes in a rodent model","year":2023,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bausch Health; National Philanthropic Trust","keywords":"Biology; Cytolethal distending toxin; Clostridium difficile toxin B; Microbiology; Intestinal permeability; Microbiome; Irritable bowel syndrome; Gene expression; Immunology; Toxin; Clostridium difficile toxin A; Gene; Clostridium difficile; Internal medicine; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000230581,0.0002716495,0.0002658943,0.0002344635,0.0001453671,0.00005256376,0.0001884038,0.00023376,0.00001054282],"category_scores_gemma":[0.0000485702,0.0002657937,0.0000586047,0.0002666954,0.00006105543,0.000008953533,0.000347615,0.0001368877,0.00005090441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005612153,"about_ca_system_score_gemma":0.00006183834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001229834,"about_ca_topic_score_gemma":0.001783482,"domain_scores_codex":[0.9983279,0.00007320897,0.0003067546,0.0006326542,0.00009625871,0.0005632624],"domain_scores_gemma":[0.9993725,0.0000184439,0.00008974688,0.0003083254,0.00005118456,0.0001597377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009880126,0.00006155839,0.01719562,0.0001055191,0.000008340018,0.000009666841,0.0005090983,0.000192869,0.9787774,0.000003217081,0.002650147,0.0003877586],"study_design_scores_gemma":[0.0009878863,0.0001635318,0.06814863,0.000208635,0.00001598098,0.00003613131,0.0002157953,0.0005828043,0.9222019,0.0000200428,0.006939981,0.0004787162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969894,0.001000137,0.0004826704,0.0006359613,0.0001535602,0.0004843538,0.0001718085,0.0000474972,0.00003456966],"genre_scores_gemma":[0.9951743,0.0005546611,0.001979152,0.0004309452,0.0001445295,0.00006732106,0.0009828712,0.00004679172,0.0006194444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05657554,"threshold_uncertainty_score":0.9999794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017232102860705,"score_gpt":0.271647685138981,"score_spread":0.254415582278276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}