{"id":"W4389883521","doi":"10.1080/19490976.2023.2293170","title":"Cytolethal distending toxin B inoculation leads to distinct gut microtypes and IBS-D-like microRNA-mediated gene expression changes in a rodent model","year":2023,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bausch Health; National Philanthropic Trust","keywords":"Biology; Cytolethal distending toxin; Clostridium difficile toxin B; Microbiology; Intestinal permeability; Microbiome; Irritable bowel syndrome; Gene expression; Immunology; Toxin; Clostridium difficile toxin A; Gene; Clostridium difficile; Internal medicine; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500175,0.0004948886,0.0003294343,0.0007168784,0.0002147407,0.0003021504,0.0001852201,0.0004261884,0.001318162],"category_scores_gemma":[0.000145088,0.0003233483,0.0005061002,0.000253414,0.0004948909,0.000252883,0.0002807755,0.0010697,0.0002900165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003143387,"about_ca_system_score_gemma":0.0002558766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006890308,"about_ca_topic_score_gemma":0.001243312,"domain_scores_codex":[0.9996886,0.00003686698,0.00003334649,0.00008925804,0.00006152937,0.00009043162],"domain_scores_gemma":[0.9997122,0.00001569782,0.0001193524,0.00002621369,0.00002147033,0.0001051485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009536013,0.0001592564,0.0008112536,0.00003359075,0.000009772855,0.0001067732,0.00003198321,0.00004309836,0.9969902,0.00004489631,0.00004462652,0.0007709121],"study_design_scores_gemma":[0.0001583792,0.006043819,0.06200819,0.00002515735,0.00007669973,0.0008543725,0.000440912,0.001582636,0.926781,0.000146458,0.001852504,0.00002975386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970216,0.0003862411,0.001223515,0.0001092379,0.00003762165,0.00005022038,0.00067293,0.0000755554,0.0004230497],"genre_scores_gemma":[0.9933727,0.0005881722,0.002149142,0.0001596837,0.0000128806,0.0001878045,0.0009053523,0.00003350333,0.002590737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001318162,"threshold_uncertainty_score":0.004409671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017232102860705,"score_gpt":0.271647685138981,"score_spread":0.254415582278276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}