{"id":"W4389891567","doi":"10.32920/24625191","title":"The Role of Mitochondrial Reactive Oxygen Species in Chondrocyte Mechanotransduction","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University; University of Toronto","funders":"","keywords":"Mechanotransduction; Reactive oxygen species; Cell biology; Chondrocyte; Chemistry; Mitochondrion; Cartilage; Stimulation; Mitochondrial ROS; MAPK/ERK pathway; Anabolism; Signal transduction; Biology; Biochemistry; In vitro; Anatomy; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003127783,0.00029373,0.0002167452,0.0003019961,0.0002664159,0.000733187,0.0001886663,0.0004959797,0.001636576],"category_scores_gemma":[0.0002206712,0.000149749,0.0002252563,0.0001714406,0.0002610342,0.0004047457,0.0003066971,0.0004545065,0.0005755276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002981253,"about_ca_system_score_gemma":0.0002213828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000317075,"about_ca_topic_score_gemma":0.000252085,"domain_scores_codex":[0.9998769,0.00002352679,0.000008749482,0.00002019341,0.00003900948,0.00003177757],"domain_scores_gemma":[0.9998989,0.00001890361,0.0000229658,0.000009006025,0.00002868361,0.00002142173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004281968,0.00009158281,0.001044664,0.0004917622,0.0000261338,0.0005740816,0.0001080062,0.0003080547,0.9724697,0.004142027,0.0005329514,0.0197829],"study_design_scores_gemma":[0.00005347033,0.0007766325,0.01928522,0.0001377732,0.00004085599,0.001525408,0.0003203801,0.002830657,0.9489633,0.004819504,0.02122188,0.00002490014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.815329,0.119638,0.03591464,0.0039453,0.001067613,0.0001668059,0.0005105101,0.0002346939,0.02319353],"genre_scores_gemma":[0.9595506,0.02506023,0.004021476,0.0001970795,0.0001587863,0.00005175281,0.0001979286,0.0000180333,0.01074413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001636576,"threshold_uncertainty_score":0.005474865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02233261130677551,"score_gpt":0.2580647998208785,"score_spread":0.235732188514103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}