{"id":"W4389892676","doi":"10.1158/2326-6066.cir-23-0498","title":"Immune-Related Colitis Is Associated with Fecal Microbial Dysbiosis and Can Be Mitigated by Fecal Microbiota Transplantation","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Legend Biotech; Juno Therapeutics; Genentech; National Institutes of Health; National Cancer Institute; Natera; Regeneron Pharmaceuticals; Memorial Sloan-Kettering Cancer Center; Amgen; Society of Memorial Sloan Kettering; Seres Therapeutics; Da Volterra; BeiGene; Cycle for Survival; Daiichi Sankyo Europe; Sanofi; Eli Lilly and Company; AstraZeneca; National Institute on Aging; Parker Institute for Cancer Immunotherapy","keywords":"Dysbiosis; Fecal bacteriotherapy; Microbiome; Medicine; Feces; Gut flora; Context (archaeology); Colitis; Transplantation; Immunology; Internal medicine; Inflammatory bowel disease; Gastroenterology; Antibiotics; Clostridium difficile; Disease; Biology; Microbiology; Bioinformatics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003254793,0.0002321904,0.0004572069,0.0002628185,0.0002363859,0.0003582411,0.00007335214,0.0001218562,0.0007298764],"category_scores_gemma":[0.0006127161,0.00008374747,0.0002565095,0.0002552312,0.0002562201,0.0001812381,0.0002485012,0.0003331952,0.0001091897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001707251,"about_ca_system_score_gemma":0.0002101077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002884458,"about_ca_topic_score_gemma":0.000561132,"domain_scores_codex":[0.9998362,0.00004639437,0.00001755787,0.00003093531,0.00002933505,0.00003957505],"domain_scores_gemma":[0.999624,0.00004749016,0.0001833386,0.00003160608,0.00002535839,0.00008815072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003577785,0.000619648,0.5719051,0.0004306373,0.0003958834,0.003010907,0.0002141516,0.00057984,0.2757641,0.0001620329,0.0006744034,0.1426655],"study_design_scores_gemma":[0.0001203307,0.00517256,0.9566172,0.00007391593,0.0001920172,0.008093839,0.0002860101,0.0009364129,0.02545393,0.0001665726,0.002873158,0.00001409248],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968209,0.001749394,0.0006737247,0.00009657796,0.00001444975,0.00001878376,0.00004534312,0.0000238785,0.0005568599],"genre_scores_gemma":[0.9985034,0.0006392362,0.0005266012,0.0001053718,0.00001813152,0.000008099867,0.00009128599,0.000004881522,0.0001029679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007298764,"threshold_uncertainty_score":0.002441704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03188858580801742,"score_gpt":0.3309719139326852,"score_spread":0.2990833281246678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}