{"id":"W4389892676","doi":"10.1158/2326-6066.cir-23-0498","title":"Immune-Related Colitis Is Associated with Fecal Microbial Dysbiosis and Can Be Mitigated by Fecal Microbiota Transplantation","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Legend Biotech; Juno Therapeutics; Genentech; National Institutes of Health; National Cancer Institute; Natera; Regeneron Pharmaceuticals; Memorial Sloan-Kettering Cancer Center; Amgen; Society of Memorial Sloan Kettering; Seres Therapeutics; Da Volterra; BeiGene; Cycle for Survival; Daiichi Sankyo Europe; Sanofi; Eli Lilly and Company; AstraZeneca; National Institute on Aging; Parker Institute for Cancer Immunotherapy","keywords":"Dysbiosis; Fecal bacteriotherapy; Microbiome; Medicine; Feces; Gut flora; Context (archaeology); Colitis; Transplantation; Immunology; Internal medicine; Inflammatory bowel disease; Gastroenterology; Antibiotics; Clostridium difficile; Disease; Biology; Microbiology; Bioinformatics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008447147,0.0002918865,0.0005436067,0.0004546961,0.0004821759,0.00006522509,0.0002189525,0.0005529131,0.0006967626],"category_scores_gemma":[0.00006542561,0.0002598653,0.0001176185,0.00181216,0.001635545,0.00008208972,0.0000699822,0.0009678759,0.00002946206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006087982,"about_ca_system_score_gemma":0.0006382967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004160872,"about_ca_topic_score_gemma":0.0008277658,"domain_scores_codex":[0.9970434,0.0004186314,0.0004703349,0.0006358516,0.0003812058,0.001050556],"domain_scores_gemma":[0.9987332,0.0002783336,0.0001075049,0.0003425071,0.0003929138,0.0001455908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006481536,0.0001218268,0.005792314,0.0001029949,0.001769919,0.0001865518,0.002010793,3.139677e-7,0.9494367,0.00001037004,0.03019411,0.003892551],"study_design_scores_gemma":[0.02338275,0.002288902,0.3446932,0.001266673,0.0003495997,0.000657507,0.001181754,0.00006991643,0.6095886,0.00003108367,0.01580206,0.0006880681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738783,0.006195221,0.000001204785,0.01722284,0.0002370225,0.0008682662,0.001167619,0.0001794772,0.00025007],"genre_scores_gemma":[0.9785977,0.01214756,0.000009197161,0.000740262,0.00003742784,0.0002009735,0.001485463,0.00007507454,0.00670634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3398482,"threshold_uncertainty_score":0.9999853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03188858580801742,"score_gpt":0.3309719139326852,"score_spread":0.2990833281246678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}