{"id":"W4389894274","doi":"10.3390/genes14122225","title":"Sex Differences in Colon Cancer: Genomic and Nongenomic Signalling of Oestrogen","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Royal College of Surgeons in Ireland","keywords":"Colorectal cancer; Biology; Wnt signaling pathway; Malignancy; Nuclear receptor; Cancer; Bioinformatics; Signalling pathways; Cancer research; Signal transduction; Signalling; Receptor; Medicine; Internal medicine; Oncology; Gene; Genetics; Transcription factor; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009560337,0.00008728646,0.0001355871,0.00005506964,0.00002910349,0.000006195939,0.00008233853,0.000107093,0.000004891595],"category_scores_gemma":[0.000005223153,0.00007834266,0.00003245208,0.00008553326,0.00005052237,0.000001207069,0.00007083204,0.00004463989,0.000004741893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006627256,"about_ca_system_score_gemma":0.00003858943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009135462,"about_ca_topic_score_gemma":0.00004660477,"domain_scores_codex":[0.9994491,0.00003312579,0.0001255812,0.0001870156,0.00004471661,0.0001604054],"domain_scores_gemma":[0.9998111,0.00001270978,0.00004317681,0.00008540463,0.00001125553,0.00003638719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002714066,0.000008665877,0.09656727,0.00001927816,0.00003947476,0.000003933159,0.000106766,0.0002236992,0.897996,0.000004779131,0.00002716091,0.004975795],"study_design_scores_gemma":[0.0004206804,0.0001850739,0.05385808,0.00001942481,0.00001995565,0.000005340557,0.0001045056,0.0005792594,0.9442006,0.00003512313,0.0004322206,0.0001396755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888417,0.01086692,0.00000641622,0.00003071481,0.00006208911,0.0001122713,0.00001244334,0.000009098573,0.00005831043],"genre_scores_gemma":[0.9920385,0.007574061,0.00004949712,0.00001219651,0.00006604377,0.00002007904,0.00002336442,0.00001161642,0.000204589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04620463,"threshold_uncertainty_score":0.3194721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116638499398747,"score_gpt":0.2395984189774585,"score_spread":0.228432033983471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}