{"id":"W4389894274","doi":"10.3390/genes14122225","title":"Sex Differences in Colon Cancer: Genomic and Nongenomic Signalling of Oestrogen","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Royal College of Surgeons in Ireland","keywords":"Colorectal cancer; Biology; Wnt signaling pathway; Malignancy; Nuclear receptor; Cancer; Bioinformatics; Signalling pathways; Cancer research; Signal transduction; Signalling; Receptor; Medicine; Internal medicine; Oncology; Gene; Genetics; Transcription factor; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002182545,0.0002566056,0.0004537405,0.0004895873,0.000181964,0.0006503472,0.0001720212,0.0003635384,0.001677305],"category_scores_gemma":[0.0003209934,0.0001084352,0.0003244621,0.0004162266,0.0004067491,0.0002974456,0.0003371284,0.0003684235,0.0003324388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003439614,"about_ca_system_score_gemma":0.0003074387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007643929,"about_ca_topic_score_gemma":0.001254183,"domain_scores_codex":[0.9998553,0.00003673234,0.00001226551,0.00003563475,0.00003462324,0.00002546378],"domain_scores_gemma":[0.9998692,0.00005889345,0.00003231351,0.000005853969,0.00002159446,0.00001212865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001496294,0.0001040825,0.03995579,0.01409898,0.0006713825,0.006358663,0.001160161,0.001793103,0.2874066,0.02862028,0.007920765,0.6104139],"study_design_scores_gemma":[0.00007439651,0.001311191,0.2979752,0.002773943,0.000935744,0.02137741,0.002004099,0.0009154917,0.07672368,0.01620983,0.5795621,0.000136989],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.07449026,0.9117044,0.002717541,0.002437971,0.0003823698,0.00001885838,0.0004236292,0.00004686043,0.007778091],"genre_scores_gemma":[0.2688845,0.7222783,0.001115023,0.0007125225,0.0003927952,0.00002188889,0.0003380057,0.00001448212,0.006242557],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001677305,"threshold_uncertainty_score":0.005611122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01116638499398747,"score_gpt":0.2395984189774585,"score_spread":0.228432033983471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}