{"id":"W4389912823","doi":"10.1038/s41531-023-00609-7","title":"Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice","year":2023,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; U.S. Department of Health and Human Services; Government of Canada; National Institutes of Health; W. Garfield Weston Foundation","keywords":"Dopamine; LRRK2; Neuroscience; Parkinson's disease; Kinase; Molecular neuroscience; Neurotransmitter; Medicine; Psychology; Biology; Internal medicine; Cell biology; Central nervous system; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003067311,0.0003289375,0.0006517395,0.0008758011,0.00003653778,0.00001093668,0.0001027397,0.0001521379,0.00008941328],"category_scores_gemma":[0.0002566591,0.0003226167,0.0001711815,0.001151025,0.0000767663,0.0001956003,0.0001066822,0.0002558892,0.00009338646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002865281,"about_ca_system_score_gemma":0.0002580876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170957,"about_ca_topic_score_gemma":0.001047378,"domain_scores_codex":[0.9975442,0.0002545797,0.0005009625,0.0007226195,0.0003882937,0.000589392],"domain_scores_gemma":[0.9988609,0.0001330513,0.0001614814,0.0004216639,0.00005516937,0.0003677599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01726253,0.009949635,0.6653073,0.001280778,0.0001212881,0.005908178,0.0004773859,0.0004571763,0.2772995,0.0003043115,0.0004257476,0.02120615],"study_design_scores_gemma":[0.008012427,0.000235858,0.9667009,0.0004686273,0.00008329162,0.000002361372,0.000143086,0.001299404,0.02129141,0.0005703349,0.0009442422,0.0002480398],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973408,0.0006448911,0.00000477892,0.0002520463,0.000116693,0.0008144078,0.0004969051,0.00008534304,0.0002441165],"genre_scores_gemma":[0.9984983,0.0003905449,0.00005432194,0.00008763926,0.00006953048,0.0002171167,0.0005594303,0.00004213745,0.00008099051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3013936,"threshold_uncertainty_score":0.9999226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02481960330498821,"score_gpt":0.2866615229646877,"score_spread":0.2618419196596995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}