{"id":"W4389914661","doi":"10.3390/nano13243167","title":"Exploring the Potential of siRNA Delivery in Acute Myeloid Leukemia for Therapeutic Silencing","year":2023,"lang":"en","type":"article","venue":"Nanomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Edmonton Civic Employees Charitable Assistance Fund; Canadian Institutes of Health Research; Women and Children's Health Research Institute; Natural Sciences and Engineering Research Council of Canada; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Transfection; Gene silencing; Survivin; Myeloid leukemia; Small interfering RNA; Cancer research; Leukemia; Cell growth; Chemistry; Cell culture; Biology; Apoptosis; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002975287,0.0001068273,0.0001588205,0.00005996793,0.00005129708,0.00002235093,0.0002193559,0.00006554505,0.0000105457],"category_scores_gemma":[0.00002093267,0.00008061188,0.00008943671,0.00009317746,0.00003476931,0.000009284168,0.00009206073,0.00002356798,0.00001329714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001765034,"about_ca_system_score_gemma":0.00006844926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005128655,"about_ca_topic_score_gemma":0.00001169569,"domain_scores_codex":[0.9991902,0.00004872252,0.0002642809,0.0001990634,0.00007717121,0.0002205645],"domain_scores_gemma":[0.9996111,0.00002208165,0.00007667703,0.0002195145,0.00005221617,0.00001834666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001775351,0.000006365879,0.00008176477,0.00002252121,0.00005348642,0.000003154234,0.0001152467,0.0002253272,0.9957391,0.0000127448,0.0002345762,0.003328159],"study_design_scores_gemma":[0.0003324199,0.0001688483,0.004612829,0.000025149,0.00002295012,0.000004745707,0.0002113021,0.0001007027,0.9937189,0.00008624588,0.0006173912,0.00009858022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986907,0.0001712388,0.0001138016,0.00005477271,0.0006555959,0.0002290027,0.00004268809,0.00001356725,0.00002865301],"genre_scores_gemma":[0.997943,0.001319357,0.00005485634,0.00009353466,0.0002207609,0.000128848,0.00006238855,0.00001703442,0.0001601989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004531065,"threshold_uncertainty_score":0.3287257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04555061690707318,"score_gpt":0.2667571363931463,"score_spread":0.2212065194860731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}