{"id":"W4389914661","doi":"10.3390/nano13243167","title":"Exploring the Potential of siRNA Delivery in Acute Myeloid Leukemia for Therapeutic Silencing","year":2023,"lang":"en","type":"article","venue":"Nanomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Edmonton Civic Employees Charitable Assistance Fund; Canadian Institutes of Health Research; Women and Children's Health Research Institute; Natural Sciences and Engineering Research Council of Canada; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Transfection; Gene silencing; Survivin; Myeloid leukemia; Small interfering RNA; Cancer research; Leukemia; Cell growth; Chemistry; Cell culture; Biology; Apoptosis; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335138,0.0003307945,0.0002093051,0.0001604725,0.0001281093,0.0003272684,0.0001732589,0.0003232811,0.0006087106],"category_scores_gemma":[0.0001579305,0.0001121708,0.0002107729,0.0001019176,0.0002008275,0.0002651373,0.000172024,0.0002747471,0.0002785486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002628586,"about_ca_system_score_gemma":0.0002449847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004769826,"about_ca_topic_score_gemma":0.0005560139,"domain_scores_codex":[0.9998931,0.00002484206,0.000008466608,0.00002599129,0.00002867556,0.00001890665],"domain_scores_gemma":[0.9999387,0.00002234053,0.00001432945,0.000004928037,0.00001257913,0.000007009377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000026286,0.00001276062,0.00007333448,0.00005068663,0.000002634901,0.00003752638,0.00001275936,0.0002355843,0.9963745,0.0002210304,0.00001846293,0.002934461],"study_design_scores_gemma":[0.000007697786,0.0002601048,0.000311267,0.000003977807,0.0000101921,0.00009946206,0.000005990092,0.001884604,0.9949055,0.00006717955,0.002440712,0.000003384548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9304074,0.0096544,0.05550627,0.000383669,0.00004429567,0.0001594776,0.0001097682,0.0002062502,0.00352858],"genre_scores_gemma":[0.9689485,0.004656069,0.02283264,0.00009807412,0.00001583673,0.00009802896,0.0001365998,0.00002726874,0.00318699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006087106,"threshold_uncertainty_score":0.002036333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04555061690707318,"score_gpt":0.2667571363931463,"score_spread":0.2212065194860731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}