{"id":"W4389914962","doi":"10.1039/d3an02022c","title":"Intramolecular aptamer switches","year":2023,"lang":"en","type":"article","venue":"The Analyst","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council","keywords":"Aptamer; Intramolecular force; Biosensor; Nanotechnology; Displacement (psychology); Molecular switch; Chemistry; Materials science; Stereochemistry; Biology; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004343619,0.0006429532,0.0003612037,0.0002414751,0.0002014088,0.0007238028,0.0007317126,0.0007329216,0.004153298],"category_scores_gemma":[0.0008007261,0.0002373396,0.0003859359,0.0002474937,0.0004020988,0.0007590548,0.000533423,0.001455628,0.001888232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002858579,"about_ca_system_score_gemma":0.0001419595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001074106,"about_ca_topic_score_gemma":0.0001431959,"domain_scores_codex":[0.9993542,0.00008179421,0.00004083816,0.0002367851,0.0001919754,0.00009445466],"domain_scores_gemma":[0.9996057,0.0001427291,0.00008106069,0.00005766589,0.00007012481,0.00004284008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000994596,0.00008252626,0.0002558626,0.0002738497,0.00002612518,0.0001471409,0.00008091238,0.0005789608,0.9560314,0.006152347,0.001200871,0.03507048],"study_design_scores_gemma":[0.00001671094,0.0003144543,0.0002630125,0.00001345649,0.00002577521,0.0004100603,0.00002137814,0.001761859,0.9640523,0.000666609,0.03243745,0.00001693536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4454327,0.02728252,0.4403823,0.0009381031,0.00244918,0.0007477904,0.001157319,0.004316169,0.07729395],"genre_scores_gemma":[0.8198642,0.00796849,0.1254303,0.001413673,0.0004094967,0.00068729,0.001115403,0.0003840634,0.04272718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004153298,"threshold_uncertainty_score":0.0138942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112029793792209,"score_gpt":0.2719794443203034,"score_spread":0.2608591463823813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}