{"id":"W4389914962","doi":"10.1039/d3an02022c","title":"Intramolecular aptamer switches","year":2023,"lang":"en","type":"article","venue":"The Analyst","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council","keywords":"Aptamer; Intramolecular force; Biosensor; Nanotechnology; Displacement (psychology); Molecular switch; Chemistry; Materials science; Stereochemistry; Biology; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002578964,0.0001073969,0.0001086497,0.00005823135,0.0001187449,0.0000226364,0.0002135696,0.00006813843,0.000003109199],"category_scores_gemma":[0.00004163912,0.00006744995,0.0001436699,0.0004491668,0.0001064288,0.000001430617,0.0001038051,0.00006761229,0.0000450446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005032064,"about_ca_system_score_gemma":0.00001235645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001815235,"about_ca_topic_score_gemma":0.00002669777,"domain_scores_codex":[0.9992952,0.00004027286,0.0001277801,0.0002242319,0.0001181284,0.0001943349],"domain_scores_gemma":[0.9993786,0.000008410691,0.00005019457,0.0004780775,0.00004946798,0.00003528512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001380453,0.00001131726,0.0004465599,0.000002521884,0.0001370198,0.00000510895,0.00001477616,0.000043197,0.9871156,0.0001102539,0.007650431,0.004449383],"study_design_scores_gemma":[0.00009033471,0.00006516225,0.0008466594,0.000005221316,0.00009562277,0.000009809302,0.0001597281,0.0005281953,0.925078,0.0006149022,0.07232506,0.0001812658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915132,0.0002105833,0.00486738,0.001470458,0.00004048979,0.00008667965,0.000006647256,0.0001419683,0.001662599],"genre_scores_gemma":[0.9970729,0.0002212365,0.0003712708,0.0005163879,0.0001686723,0.000006281592,0.00009537939,0.00001450871,0.001533372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06467462,"threshold_uncertainty_score":0.2750529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112029793792209,"score_gpt":0.2719794443203034,"score_spread":0.2608591463823813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}