{"id":"W4389923980","doi":"10.1186/s40478-023-01705-8","title":"Targeting RACK1 to alleviate TDP-43 and FUS proteinopathy-mediated suppression of protein translation and neurodegeneration","year":2023,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amorfix (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research; University of Toronto; Consortium canadien en neurodégénérescence associée au vieillissement; Fondation Brain Canada; ALS Society of Canada","keywords":"Neurodegeneration; Neuroscience; Translation (biology); Neurology; Medicine; Biology; Disease; Pathology; Messenger RNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002051498,0.0007030087,0.0005778794,0.0004043808,0.0003338655,0.000331326,0.0004280019,0.0005369285,0.001232801],"category_scores_gemma":[0.0001010128,0.0002268523,0.0005300637,0.0002476308,0.0004339816,0.00029912,0.0002951327,0.000914381,0.000364946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004927571,"about_ca_system_score_gemma":0.0003976818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007661307,"about_ca_topic_score_gemma":0.001085556,"domain_scores_codex":[0.9997106,0.0000360392,0.00004521614,0.00006730415,0.00005476221,0.0000860089],"domain_scores_gemma":[0.9998815,0.000009828772,0.00004055005,0.00001231036,0.00001460721,0.00004114026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002503719,0.00009809398,0.00007082756,0.0001203365,0.00001418974,0.00008936355,0.00002677064,0.0001281383,0.9977521,0.0002301377,0.0001176186,0.001102087],"study_design_scores_gemma":[0.00008197915,0.000764527,0.002507091,0.00001572985,0.00004995977,0.0003955695,0.00006714467,0.00269643,0.9891339,0.0001166425,0.00415913,0.00001194564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910867,0.002471683,0.003130392,0.0003095605,0.0001725116,0.0001116986,0.0008895746,0.0003526934,0.001475258],"genre_scores_gemma":[0.9928216,0.001223543,0.00211789,0.00008309285,0.00002051757,0.0001518638,0.0005968219,0.00003709446,0.002947597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001232801,"threshold_uncertainty_score":0.004124165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08867280249585376,"score_gpt":0.325473228212502,"score_spread":0.2368004257166482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}