{"id":"W4389935779","doi":"10.1016/j.xcrm.2023.101341","title":"Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity","year":2023,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre","funders":"Instituto de Salud Carlos III; Biotechnology and Biological Sciences Research Council; Medical Research Council; Generalitat de Catalunya; European Regional Development Fund; Horizon 2020 Framework Programme; European Social Fund; Centres de Recerca de Catalunya","keywords":"Biology; Gut flora; Histidine; Catabolism; Steatosis; Fatty liver; Lipogenesis; Biochemistry; Internal medicine; Lipid metabolism; Endocrinology; Metabolism; Medicine; Disease; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002316292,0.0001219436,0.0001806965,0.00005309384,0.00007019816,0.000002934694,0.0001262896,0.00008227929,0.00002621185],"category_scores_gemma":[0.00002370682,0.00007643851,0.00002964201,0.0002262898,0.0001656709,0.000001945431,0.00005747373,0.00009937966,0.000002762954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001735362,"about_ca_system_score_gemma":0.00009798785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003193634,"about_ca_topic_score_gemma":0.00005694168,"domain_scores_codex":[0.9990134,0.00003264222,0.0003451967,0.000284415,0.0001038167,0.0002205225],"domain_scores_gemma":[0.999096,0.000009632066,0.0002199839,0.0005080283,0.0001081092,0.00005825581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002141555,0.0001067823,0.06741741,0.00003506613,0.00001154929,0.00000700987,0.00008935734,0.000007060845,0.9028527,0.00000435961,0.02910377,0.0003435285],"study_design_scores_gemma":[0.0008556859,0.0002084507,0.9242486,0.0000336663,0.0000432201,0.00004144043,0.00007314348,0.000002509267,0.03875658,0.00003385349,0.03558002,0.0001228238],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962367,0.001400623,0.00008374883,0.001287758,0.0001777068,0.0003473205,0.00002972986,0.00001017416,0.0004262436],"genre_scores_gemma":[0.9968336,0.0003329512,0.00001878204,0.0003796935,0.00007997223,0.00001234875,0.001054782,0.00001720612,0.001270677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8640961,"threshold_uncertainty_score":0.3117072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006173513805528729,"score_gpt":0.2370467062282461,"score_spread":0.2308731924227174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}