{"id":"W4389938339","doi":"10.7554/elife.91883.1.sa0","title":"Reviewer #2 (Public Review): BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Corneal Surgery and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Osteoporosis Canada","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Microtia; Chondrocyte; Bone morphogenetic protein; Cell biology; Protein kinase A; Chemistry; Kinase; Medicine; Anatomy; Biology; Cartilage; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02638978,0.001831445,0.003307106,0.004637811,0.003257598,0.00910628,0.005112614,0.01696024,0.1101419],"category_scores_gemma":[0.1675176,0.001169235,0.002726403,0.002361407,0.002331179,0.004565756,0.003687283,0.006011757,0.05630495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006078864,"about_ca_system_score_gemma":0.01102063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003005283,"about_ca_topic_score_gemma":0.005238201,"domain_scores_codex":[0.9783108,0.004767278,0.00357766,0.002009072,0.01015675,0.00117846],"domain_scores_gemma":[0.7043232,0.01648376,0.01052003,0.006334659,0.2506848,0.01165362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003027521,0.000005147377,0.00006928168,0.0008008064,0.00001164276,0.00003973102,0.00002041117,0.00001014641,0.00005981997,0.00008268827,0.9933491,0.005520943],"study_design_scores_gemma":[0.0001729707,0.00004115578,0.001153629,0.002774362,0.00006634225,0.0003506909,0.0001354456,0.0001483401,0.0002642165,0.0006558927,0.9941855,0.00005139456],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"other","genre_scores_codex":[0.0003160296,0.008597921,0.001002391,0.2432753,0.7334829,0.001351549,0.002053049,0.000863437,0.009057347],"genre_scores_gemma":[0.008353779,0.01618494,0.002367046,0.3125766,0.5420735,0.004924957,0.002740464,0.001418227,0.1093604],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.1101419,"threshold_uncertainty_score":0.3684615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04826933494772875,"score_gpt":0.3190193303402111,"score_spread":0.2707499953924823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}