{"id":"W4389938382","doi":"10.7554/elife.92510","title":"Pigmentation level of human iPSC-derived RPE does not indicate a specific gene expression profile","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Palette (Canada)","funders":"RIKEN; Japan Society for the Promotion of Science","keywords":"Retinal pigment epithelium; Induced pluripotent stem cell; Gene expression; Biology; Cell biology; Cell; Gene; Retinal; Cell type; Genetics; Embryonic stem cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000119372,0.00009392755,0.00009282008,0.00006019,0.00007535904,0.00001076402,0.0001133849,0.00007220366,0.00008138589],"category_scores_gemma":[0.00001914566,0.00007496764,0.00004504548,0.00009728328,0.00004421981,0.000003739142,0.00008913588,0.00003519164,0.00005609668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006402784,"about_ca_system_score_gemma":0.0000283023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008420829,"about_ca_topic_score_gemma":0.000005976298,"domain_scores_codex":[0.9992412,0.00002804093,0.0001883993,0.0002178149,0.0001787144,0.0001458135],"domain_scores_gemma":[0.9996597,0.000004702629,0.00009757157,0.0001541489,0.0000436406,0.00004028809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005284432,0.00002464177,0.00513985,0.0000160095,0.0000121485,0.000001318269,0.0001841437,0.000003503569,0.9854824,0.0000101171,0.008455175,0.000617869],"study_design_scores_gemma":[0.0004018172,0.00006484857,0.07207844,0.00001298043,0.000003114082,3.453402e-7,0.0001919441,0.000003862755,0.9244359,0.00002718844,0.00267592,0.0001036515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985542,0.00006354534,0.0002703723,0.0001154904,0.0001043825,0.0001589903,0.00003280835,0.00001983061,0.0006803443],"genre_scores_gemma":[0.9955528,0.000289207,0.001077952,0.00007717279,0.00008356312,0.00003325596,0.00077853,0.00001499932,0.002092464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06693859,"threshold_uncertainty_score":0.3057092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05786682236168442,"score_gpt":0.2995908009745483,"score_spread":0.2417239786128639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}