{"id":"W4389938403","doi":"10.7554/elife.88936.3.sa0","title":"Reviewer #3 (Public Review): Detection of new pioneer transcription factors as cell-type specific nucleosome binders","year":2023,"lang":"en","type":"peer-review","venue":"","topic":"Animal Genetics and Reproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. National Library of Medicine; Biotechnology and Biological Sciences Research Council; Cancer Research UK; National Institutes of Health; Central China Normal University; Natural Sciences and Engineering Research Council of Canada; Queen's University; National Natural Science Foundation of China","keywords":"Nucleosome; Computational biology; Transcription factor; Biology; Genetics; DNA; Histone; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0329852,0.001734423,0.003420787,0.004683287,0.003992991,0.00818107,0.005279796,0.01698738,0.0687832],"category_scores_gemma":[0.1969806,0.001169276,0.002554529,0.00293747,0.002554261,0.004617339,0.003701876,0.007141264,0.04117806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005244605,"about_ca_system_score_gemma":0.01312425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003348396,"about_ca_topic_score_gemma":0.005884755,"domain_scores_codex":[0.9753751,0.005625893,0.003449389,0.002637072,0.01146153,0.001451031],"domain_scores_gemma":[0.613087,0.03073637,0.01465086,0.009682268,0.3133241,0.01851951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003548137,0.000005750389,0.0001243385,0.0005539263,0.00001363373,0.00004334014,0.00002065674,0.00001429443,0.00006559486,0.00007939568,0.9949708,0.004072882],"study_design_scores_gemma":[0.0001674047,0.00004372334,0.001638991,0.001460368,0.00008167513,0.0002954118,0.000140863,0.0002279752,0.0003941927,0.0008197959,0.994664,0.00006565091],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"other","genre_scores_codex":[0.0004291305,0.005778342,0.001372485,0.2921553,0.6909865,0.0009143341,0.002188313,0.0008586087,0.005317031],"genre_scores_gemma":[0.00860474,0.01218061,0.00312227,0.3847966,0.5004117,0.003529378,0.003101796,0.001633457,0.08261939],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.0687832,"threshold_uncertainty_score":0.2301027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05254719301248543,"score_gpt":0.2871667126665431,"score_spread":0.2346195196540577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}