{"id":"W4389938979","doi":"10.7554/elife.91883","title":"BMP signaling maintains auricular chondrocyte identity and prevents microtia development by inhibiting protein kinase A","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Osteoporosis Canada","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Microtia; Chondrocyte; Cell biology; Protein kinase A; Zebrafish; Signal transduction; Kinase; Anatomy; Chemistry; Biology; Cartilage; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457288,0.0002928843,0.0002624364,0.0002920261,0.0001866545,0.0003777126,0.0002389911,0.0002261101,0.001622392],"category_scores_gemma":[0.0001366751,0.0001646647,0.0003153933,0.0001056723,0.0003168025,0.0001719146,0.0002647654,0.0008392248,0.000562965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002010525,"about_ca_system_score_gemma":0.0003456018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008646845,"about_ca_topic_score_gemma":0.001434334,"domain_scores_codex":[0.9997908,0.00001836549,0.00002036431,0.0000469771,0.00006400979,0.00005946986],"domain_scores_gemma":[0.9998922,0.00001208184,0.00003127483,0.00001238938,0.00001220109,0.00003991606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000159754,0.00002195316,0.0001978615,0.0000535014,0.000007116702,0.00004011031,0.000008880645,0.00004707302,0.997424,0.0001099504,0.00008668728,0.001843053],"study_design_scores_gemma":[0.00002660807,0.0001654035,0.004884424,0.000008573047,0.00001873612,0.0001686484,0.00004298969,0.0008273475,0.9893361,0.00006478818,0.00445229,0.00000396483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855639,0.003698316,0.005473354,0.0003021067,0.0001274796,0.00005249376,0.001262676,0.0003139681,0.003205689],"genre_scores_gemma":[0.9896501,0.001652983,0.002856641,0.00008522532,0.00001853539,0.00004509893,0.0007582835,0.00004245404,0.004890669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001622392,"threshold_uncertainty_score":0.00542742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02495870698881262,"score_gpt":0.3083381953253477,"score_spread":0.283379488336535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}