{"id":"W4389943594","doi":"10.1182/bloodadvances.2023011492","title":"Bendamustine lymphodepletion before axicabtagene ciloleucel is safe and associates with reduced inflammatory cytokines","year":2023,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pharmacyclics; Genentech; Adaptive Biotechnologies; Juno Therapeutics; Incyte; BeiGene; Loxo Oncology; TG Therapeutics; University of Pennsylvania; Seagen; Kite Pharma; Society for Immunotherapy of Cancer; Mallinckrodt Pharmaceuticals; Atara Biotherapeutics; Daiichi Sankyo Europe; National Cancer Institute; Gilead Sciences; GlaxoSmithKline; Regeneron Pharmaceuticals; Leukemia and Lymphoma Society; Legend Biotech; MorphoSys; Celgene; AstraZeneca; Bristol-Myers Squibb","keywords":"Medicine; Bendamustine; Immunology; Lymphoma; Rituximab","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003007789,0.0002098696,0.0003478128,0.0001992401,0.0001495078,0.00003387582,0.00009381472,0.00009192665,0.0004775451],"category_scores_gemma":[0.0001238289,0.000161628,0.00006127268,0.0005281441,0.0001532134,0.0001706605,0.00007026947,0.0001559433,0.0000443784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004994732,"about_ca_system_score_gemma":0.0001171177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002397802,"about_ca_topic_score_gemma":0.00007162312,"domain_scores_codex":[0.9983712,0.00004152109,0.0002404646,0.0004038543,0.0005279949,0.0004149725],"domain_scores_gemma":[0.9991848,0.0001054577,0.0001012648,0.0002806347,0.0001583819,0.0001694115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009654122,0.0002051806,0.254979,0.0005747236,0.0004924662,0.0003391813,0.001385915,0.00002664032,0.6215054,0.00009768044,0.001266403,0.118162],"study_design_scores_gemma":[0.01101311,0.00233324,0.4996428,0.0006586338,0.000460926,0.000352532,0.001088235,0.0003841704,0.3331989,0.0008298041,0.1493814,0.0006562213],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932275,0.001865515,0.000005297359,0.002130748,0.00007623614,0.0004053641,0.00003663399,0.000235145,0.002017539],"genre_scores_gemma":[0.9731776,0.00374374,0.0009499578,0.0003738946,0.0006174473,0.0001059508,0.0001270646,0.00008509496,0.02081928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2883064,"threshold_uncertainty_score":0.6590998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482610376192952,"score_gpt":0.2868707754483552,"score_spread":0.2720446716864257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}