{"id":"W4389943924","doi":"10.1038/s41467-023-44297-6","title":"Antigen recognition reinforces regulatory T cell mediated Leishmania major persistence","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Government of Canada; University of Manitoba; Research Manitoba","keywords":"Leishmania major; Biology; Leishmania; Effector; Immunology; Cutaneous leishmaniasis; Antigen; T cell; Transgene; Immune system; Leishmaniasis; Cell biology; Parasite hosting; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005894845,0.00016164,0.0002612271,0.0003667669,0.0006497999,0.00004180615,0.0007739933,0.0002990325,0.00009447312],"category_scores_gemma":[0.001182631,0.0001488671,0.000133506,0.001272662,0.0003543468,0.0001907871,0.0005372945,0.001190981,0.001245402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001274002,"about_ca_system_score_gemma":0.0001550062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000325025,"about_ca_topic_score_gemma":0.0001934961,"domain_scores_codex":[0.9983992,0.00014936,0.0003010974,0.0002703915,0.0005276845,0.000352283],"domain_scores_gemma":[0.9966006,0.0005654648,0.000111792,0.001992224,0.0005727413,0.0001571762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.000388621,0.0009499477,0.123821,0.0007353259,0.001099683,0.0001810873,0.00774087,0.00001362914,0.1207374,0.00218301,0.7149246,0.02722482],"study_design_scores_gemma":[0.001862262,0.0002476924,0.6905267,0.0003416463,0.0001488145,0.00005453218,0.004045847,0.00196988,0.009430383,0.0002956389,0.290585,0.0004916684],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.823502,0.01895463,0.000008790713,0.03976135,0.0002738594,0.001347197,0.0001174303,0.001157484,0.1148772],"genre_scores_gemma":[0.9776738,0.01508307,0.002163377,0.000677623,0.00008016033,0.0001147827,0.0009999936,0.00003519904,0.003171936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5667056,"threshold_uncertainty_score":0.9995322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06483406145812178,"score_gpt":0.3280538850486856,"score_spread":0.2632198235905638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}