{"id":"W4389945058","doi":"10.1161/circ.148.suppl_1.14752","title":"Abstract 14752: FGF-23, Cardiovascular Events, and the Benefit of Canagliflozin in the CANVAS Trial","year":2023,"lang":"en","type":"article","venue":"Circulation","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto","funders":"","keywords":"Medicine; Mace; Canagliflozin; Hazard ratio; Internal medicine; Proportional hazards model; Clinical endpoint; Quartile; Fibroblast growth factor 23; Diabetes mellitus; Randomized controlled trial; Gastroenterology; Type 2 diabetes; Confidence interval; Endocrinology; Myocardial infarction; Percutaneous coronary intervention","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002028752,0.0007130108,0.001559918,0.0002140587,0.0001879608,0.0011826,0.0004139444,0.001133778,0.006117172],"category_scores_gemma":[0.002671677,0.0002027376,0.001055677,0.0003646733,0.0004751069,0.0005173614,0.0004018741,0.001783724,0.0005867749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002765906,"about_ca_system_score_gemma":0.0005429788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004790038,"about_ca_topic_score_gemma":0.0009001126,"domain_scores_codex":[0.999199,0.0004994989,0.00003502751,0.00009062201,0.0001053056,0.00007060362],"domain_scores_gemma":[0.9990188,0.0003959392,0.0001881064,0.00007403189,0.00006452813,0.0002585293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9240415,0.001563079,0.009760208,0.002345448,0.006031865,0.0001447815,0.00004945687,0.001332278,0.001487797,0.00102622,0.01216815,0.04004934],"study_design_scores_gemma":[0.9099408,0.03250235,0.03665565,0.0004050654,0.007179329,0.0002352748,0.00004536011,0.00313542,0.0007216173,0.001747238,0.007382651,0.00004921516],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.930378,0.03883949,0.0009808654,0.004370956,0.001590953,0.001246529,0.004079965,0.0002039541,0.01830927],"genre_scores_gemma":[0.9825271,0.003977436,0.001145723,0.002477853,0.001640856,0.001403373,0.003170367,0.00002171854,0.003635607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006117172,"threshold_uncertainty_score":0.02046394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0225265488576743,"score_gpt":0.2674480659482659,"score_spread":0.2449215170905916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}