{"id":"W4389948140","doi":"10.1158/1055-9965.epi-23-0717","title":"Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk","year":2023,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Nutritional Studies and Diet","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; National Institute on Aging; NIHR Imperial Biomedical Research Centre; Instituto de Salud Carlos III; National Institute for Health and Care Research; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Health and Medical Research Council; Medical Research Council; Centers for Disease Control and Prevention; World Health Organization; Xarxa de Bancs de Tumors de Catalunya; Junta de Castilla y León; National Institutes of Health; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; Institut Gustave-Roussy; National Human Genome Research Institute; Cancer Council Victoria; School of Public Health, Imperial College London; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Mutuelle Générale de l'Education Nationale; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Cancerfonden; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Marshfield Clinic Research Foundation; Institut National de la Santé et de la Recherche Médicale; Deutsche Forschungsgemeinschaft; Centres de Recerca de Catalunya; Imperial College London; Generalitat de Catalunya; Food Standards Agency; Swedish Cancer Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Brigham and Women's Hospital; Center for Strategic Scientific Initiatives, National Cancer Institute; Division of Cancer Prevention, National Cancer Institute; Harvard T.H. Chan School of Public Health; Victorian Cancer Agency; Conseil Régional des Pays de la Loire; University of Pittsburgh; Johns Hopkins University; Association Anne de Bretagne Genetique; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Fred Hutchinson Cancer Research Center; Emory University; Damon Runyon Cancer Research Foundation; Cancer Research UK; American Cancer Society; U.S. Department of Health and Human Services","keywords":"Red meat; Colorectal cancer; Processed meat; Confidence interval; Medicine; Genome-wide association study; Genotyping; Quartile; Single-nucleotide polymorphism; Internal medicine; Cancer; Genetics; Biology; Genotype; Food science; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00401169,0.0008487946,0.001241729,0.002314521,0.0003927308,0.0008156889,0.0006361615,0.0005996501,0.002612873],"category_scores_gemma":[0.004973639,0.0003666837,0.005062834,0.002466382,0.0003941091,0.0005187354,0.0007844622,0.001035424,0.0001451378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003649109,"about_ca_system_score_gemma":0.0007239481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002999029,"about_ca_topic_score_gemma":0.006194478,"domain_scores_codex":[0.9967577,0.002090309,0.0001799223,0.0005514811,0.0002369554,0.0001836816],"domain_scores_gemma":[0.9951348,0.003463477,0.0006066228,0.0004484369,0.0001807248,0.0001659296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003327139,0.0002112903,0.8570831,0.001085879,0.09861534,0.0006207937,0.0002581004,0.003399724,0.008504526,0.0006633872,0.0008978911,0.02533279],"study_design_scores_gemma":[0.0002877194,0.001092256,0.9498781,0.00009013699,0.03405532,0.0005365585,0.0001933136,0.00687857,0.001711378,0.002486869,0.002745287,0.00004456423],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9529885,0.02574958,0.01672555,0.0008477275,0.0001148281,0.00008874733,0.002182335,0.0002103306,0.001092462],"genre_scores_gemma":[0.9936939,0.001109664,0.004057647,0.0001668265,0.00004765376,0.00006369314,0.0005698306,0.00002281351,0.0002680237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00401169,"threshold_uncertainty_score":0.02121609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1800763615248682,"score_gpt":0.4125293850306114,"score_spread":0.2324530235057432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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