{"id":"W4389949429","doi":"10.1111/all.15966","title":"Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy","year":2023,"lang":"en","type":"article","venue":"Allergy","topic":"Food Allergy and Anaphylaxis Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Health and Medical Research Council; National Institutes of Health; Alfred Research Trusts, Alfred Health","keywords":"Peanut allergy; Medicine; Tolerability; Allergy; Placebo; Immunology; Anaphylaxis; Allergen; Adverse effect; Clinical trial; Immunotherapy; Food allergy; Internal medicine; Immune system; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002260837,0.001000476,0.001561409,0.0002540028,0.0003062629,0.0007095754,0.0006917494,0.001652452,0.009618538],"category_scores_gemma":[0.001439115,0.0002566428,0.001078851,0.00022654,0.000639824,0.0006993005,0.0002031078,0.001978796,0.001173399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003841639,"about_ca_system_score_gemma":0.001007471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002647144,"about_ca_topic_score_gemma":0.000408133,"domain_scores_codex":[0.9993259,0.0003932168,0.00003592337,0.0001001567,0.00005858189,0.00008618455],"domain_scores_gemma":[0.9988841,0.0003889463,0.0002293172,0.0001251818,0.0001160453,0.0002562606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9033608,0.009679541,0.001018282,0.001613548,0.0007438021,0.0001416774,0.00007953183,0.0006712685,0.02419732,0.0004068798,0.002814937,0.05527235],"study_design_scores_gemma":[0.6376219,0.35114,0.002722493,0.0001226776,0.0004181724,0.0001768569,0.00001982579,0.0005238396,0.003741251,0.0004956651,0.00300264,0.00001457244],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9630264,0.01268843,0.002897447,0.001478003,0.0007578682,0.00980926,0.003660873,0.0002726958,0.005409013],"genre_scores_gemma":[0.98015,0.003351737,0.002758351,0.0009018921,0.0005978285,0.005414743,0.002047075,0.00003403446,0.00474429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009618538,"threshold_uncertainty_score":0.03217727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04592641290746063,"score_gpt":0.3597887305688431,"score_spread":0.3138623176613825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}