{"id":"W4389949429","doi":"10.1111/all.15966","title":"Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy","year":2023,"lang":"en","type":"article","venue":"Allergy","topic":"Food Allergy and Anaphylaxis Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Health and Medical Research Council; National Institutes of Health; Alfred Research Trusts, Alfred Health","keywords":"Peanut allergy; Medicine; Tolerability; Allergy; Placebo; Immunology; Anaphylaxis; Allergen; Adverse effect; Clinical trial; Immunotherapy; Food allergy; Internal medicine; Immune system; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004249717,0.0001361978,0.0004027728,0.0002443946,0.0000701976,0.000005387362,0.00008771635,0.0001167196,0.0003635113],"category_scores_gemma":[0.00009605271,0.0001211944,0.0001804199,0.0002485282,0.0000886359,0.00006501054,0.00004166149,0.0001060265,0.000004240998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001878265,"about_ca_system_score_gemma":0.0001196642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001101754,"about_ca_topic_score_gemma":0.0001051083,"domain_scores_codex":[0.9986905,0.0000477847,0.000428736,0.0002419711,0.0003146064,0.0002763441],"domain_scores_gemma":[0.9991933,0.000155836,0.0001416948,0.0002615629,0.0001470729,0.000100583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.2737726,0.002352125,0.000007570485,0.0005154562,0.002689057,0.00005995373,0.001255354,0.00003390473,0.5407789,0.03069627,0.01219372,0.1356451],"study_design_scores_gemma":[0.2367076,0.02457235,0.0007651743,0.000207504,0.00001899677,0.0000347644,0.001080566,0.002390468,0.1586045,0.004123334,0.5711067,0.0003880448],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920794,0.0004677654,0.001195862,0.001524504,0.0004322677,0.001138209,0.00007897712,0.00009290691,0.002990051],"genre_scores_gemma":[0.9884002,0.005291232,0.0002918227,0.0000715164,0.0002084037,0.00005319685,0.0002576694,0.00003741027,0.005388499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.558913,"threshold_uncertainty_score":0.4942164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04592641290746063,"score_gpt":0.3597887305688431,"score_spread":0.3138623176613825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}