{"id":"W4389951300","doi":"10.1111/cts.13682","title":"Pharmacokinetics, safety, and efficacy of cedirogant from phase I studies in healthy participants and patients with chronic plaque psoriasis","year":2023,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eli Lilly and Company; Galderma; Incyte; Bausch Health; Arbor Pharmaceuticals; Regeneron Pharmaceuticals; Genentech; Coherus Biosciences; Valeant Pharmaceuticals International; Sanofi; Amgen; Pfizer","keywords":"Plaque psoriasis; Medicine; Psoriasis; Pharmacokinetics; MEDLINE; Dermatology; Intensive care medicine; Internal medicine; Pharmacology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004372525,0.00009127094,0.0002467567,0.00007023868,0.0001389021,0.000005052036,0.00005828473,0.00005371046,0.00001810116],"category_scores_gemma":[0.00007795737,0.00006353905,0.00001792541,0.000240293,0.001471315,0.00008077268,0.0000331271,0.00007482832,0.000003733244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005531973,"about_ca_system_score_gemma":0.00007598435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002941373,"about_ca_topic_score_gemma":0.00007716377,"domain_scores_codex":[0.9989974,0.00007925794,0.0003369911,0.0003154276,0.00006268961,0.0002081889],"domain_scores_gemma":[0.9988844,0.0008945211,0.00006509283,0.00006140063,0.00004365322,0.0000509486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003055212,0.0004888164,0.8270885,0.00002517826,0.0001448442,0.000003920032,0.0008661716,0.00001437817,0.001220692,0.0002260895,0.00001339464,0.1668528],"study_design_scores_gemma":[0.01468721,0.0006420492,0.9832547,0.00004644393,0.00007321783,6.653178e-7,0.0000379031,0.00006908033,0.0005504847,0.000258594,0.0003026514,0.00007694445],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949322,0.003997155,0.000007331997,0.0004238197,0.0002304919,0.0001724962,0.0002161464,0.00001137652,0.000008988103],"genre_scores_gemma":[0.9954941,0.004316714,0.00006111831,0.00002905761,0.0000249384,0.000005753345,0.00005656644,0.000003067192,0.000008633651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1667759,"threshold_uncertainty_score":0.5421121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1009929063500124,"score_gpt":0.4030187458181245,"score_spread":0.3020258394681121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}