{"id":"W4389951300","doi":"10.1111/cts.13682","title":"Pharmacokinetics, safety, and efficacy of cedirogant from phase I studies in healthy participants and patients with chronic plaque psoriasis","year":2023,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eli Lilly and Company; Galderma; Incyte; Bausch Health; Arbor Pharmaceuticals; Regeneron Pharmaceuticals; Genentech; Coherus Biosciences; Valeant Pharmaceuticals International; Sanofi; Amgen; Pfizer","keywords":"Plaque psoriasis; Medicine; Psoriasis; Pharmacokinetics; MEDLINE; Dermatology; Intensive care medicine; Internal medicine; Pharmacology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002258231,0.0005471203,0.001163241,0.0002474286,0.0003931202,0.0006975011,0.0002761202,0.0006986457,0.00157132],"category_scores_gemma":[0.001760868,0.0003850218,0.0009116073,0.000257794,0.0004210107,0.0004436277,0.0003145774,0.001201514,0.0002854562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003764413,"about_ca_system_score_gemma":0.000465002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003693339,"about_ca_topic_score_gemma":0.0006878134,"domain_scores_codex":[0.9992436,0.0003524499,0.00007205721,0.0001317463,0.0001283262,0.00007180004],"domain_scores_gemma":[0.9989353,0.0003577184,0.0002583796,0.0001348197,0.0001305646,0.0001832851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2475584,0.01541741,0.110962,0.001812587,0.003223071,0.0008996706,0.00165416,0.002451246,0.389413,0.0004343782,0.002767251,0.2234068],"study_design_scores_gemma":[0.0737898,0.5429104,0.295891,0.0001359977,0.004253879,0.003540311,0.0005033726,0.001871442,0.06247339,0.0004429412,0.01402487,0.0001626742],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932248,0.003453202,0.001161505,0.0001043492,0.00002216894,0.0005534479,0.0004158693,0.00003898678,0.001025724],"genre_scores_gemma":[0.9954067,0.001142691,0.001229736,0.0002336139,0.00004146287,0.000410544,0.0009420941,0.0000104507,0.000582794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002258231,"threshold_uncertainty_score":0.0119428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1009929063500124,"score_gpt":0.4030187458181245,"score_spread":0.3020258394681121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}